InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TFAP2B

Summary

InnateDB Gene

IDBG-90393.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TFAP2B

Gene Name

transcription factor AP-2 beta (activating enhancer binding protein 2 beta)

Synonyms

AP-2B; AP2-B

Species

Homo sapiens

Ensembl Gene

ENSG00000008196

Encoded Proteins

IDBP-90397

transcription factor AP-2 beta (activating enhancer binding protein 2 beta)

IDBP-243187

transcription factor AP-2 beta (activating enhancer binding protein 2 beta)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members differ in their expression patterns and binding affinity for different promoters. This protein functions as both a transcriptional activator and repressor. Mutations in this gene result in autosomal dominant Char syndrome, suggesting that this gene functions in the differentiation of neural crest cell derivatives. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:50818723-50847613

Strand

Forward strand

Band

p12.3

Transcripts

ENST00000344788	ENSP00000342252
ENST00000393655	ENSP00000377265
ENST00000489228

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0000983	RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001105	RNA polymerase II transcription coactivator activity
GO:0001106	RNA polymerase II transcription corepressor activity
GO:0001158	enhancer sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001822	kidney development
GO:0003091	renal water homeostasis
GO:0006006	glucose metabolic process
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007423	sensory organ development
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0010226	response to lithium ion
GO:0010842	retina layer formation
GO:0010960	magnesium ion homeostasis
GO:0030510	regulation of BMP signaling pathway
GO:0035136	forelimb morphogenesis
GO:0035137	hindlimb morphogenesis
GO:0035810	positive regulation of urine volume
GO:0035909	aorta morphogenesis
GO:0042493	response to drug
GO:0042593	glucose homeostasis
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0043525	positive regulation of neuron apoptotic process
GO:0043588	skin development
GO:0045444	fat cell differentiation
GO:0045595	regulation of cell differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048485	sympathetic nervous system development
GO:0050796	regulation of insulin secretion
GO:0055062	phosphate ion homeostasis
GO:0055074	calcium ion homeostasis
GO:0055075	potassium ion homeostasis
GO:0055078	sodium ion homeostasis
GO:0072017	distal tubule development
GO:0072044	collecting duct development
GO:0072210	metanephric nephron development
GO:0097070	ductus arteriosus closure
GO:0097275	cellular ammonia homeostasis
GO:0097276	cellular creatinine homeostasis
GO:0097277	cellular urea homeostasis

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000025927

View Gene Order

ENSBTAG00000020426

Not yet available

Cross-References

SwissProt

Q92481

TrEMBL

A8K557

UniProt Splice Variant

Entrez Gene

7021

UniGene

Hs.33102

RefSeq

NM_003221 XM_006715178

HUGO

HGNC:11743

OMIM

601601

CCDS

CCDS4934

HPRD

03360

IMGT

EMBL

AJ278356 AK291172 AL031224 AL049693 BC037225 X95694 Y09912

GenPept

AAH37225 BAF83861 CAA64990 CAA71047 CAB41305 CAB89563 CAC01130 CAI20235

RNA Seq Atlas

7021