Homo sapiens Gene: IFT140
Summary
InnateDB Gene IDBG-9054.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IFT140
Gene Name intraflagellar transport 140 homolog (Chlamydomonas)
Synonyms c305C8.4; c380F5.1; gs114; MZSDS; SRTD9; WDTC2;
Species Homo sapiens
Ensembl Gene ENSG00000187535
Encoded Proteins
intraflagellar transport 140 homolog (Chlamydomonas)
intraflagellar transport 140 homolog (Chlamydomonas)
intraflagellar transport 140 homolog (Chlamydomonas)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes one of the subunits of the intraflagellar transport (IFT) complex A. Intraflagellar transport is involved in the genesis, resorption and signaling of primary cilia. The primary cilium is a microtubule-based sensory organelle at the surface of most quiescent mammalian cells, that receives signals from its environment, such as the flow of fluid, light or odors, and transduces those signals to the nucleus. Loss of the corresponding protein in mouse results in renal cystic disease. [provided by RefSeq, Jun 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:1510427-1612110
Strand Reverse strand
Band p13.3
Transcripts
ENST00000361339 ENSP00000354895
ENST00000397417 ENSP00000380562
ENST00000426508 ENSP00000406012
ENST00000439987
ENST00000568837 ENSP00000458439
ENST00000561954
ENST00000566818
ENST00000566052
ENST00000569812 ENSP00000457092
ENST00000565298
ENST00000569646 ENSP00000454781
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0042384 cilium assembly
GO:0048705 skeletal system morphogenesis
GO:0060041 retina development in camera-type eye
GO:0060271 cilium morphogenesis
GO:0061512 protein localization to cilium
GO:0072001 renal system development
GO:1902017 regulation of cilium assembly
Cellular Component
GO:0005813 centrosome
GO:0005929 cilium
GO:0005930 axoneme
GO:0030991 intraciliary transport particle A
GO:0032391 photoreceptor connecting cilium
GO:0036064 ciliary basal body
GO:0072372 primary cilium
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Signaling by Hedgehog pathway
Signal Transduction pathway
Hedgehog 'off' state pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.389438
RefSeq NM_014714 XM_006720989 XM_006720990 XM_006720991 XM_006720992
HUGO
OMIM
CCDS CCDS10439
HPRD 11093
IMGT
EMBL
GenPept
RNA Seq Atlas