Homo sapiens Gene: SLC18A2
Summary
InnateDB Gene IDBG-90795.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC18A2
Gene Name solute carrier family 18 (vesicular monoamine), member 2
Synonyms SVAT; SVMT; VAT2; VMAT2;
Species Homo sapiens
Ensembl Gene ENSG00000165646
Encoded Proteins
solute carrier family 18 (vesicular monoamine), member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The vesicular monoamine transporter acts to accumulate cytosolic monoamines into synaptic vesicles, using the proton gradient maintained across the synaptic vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (summary by Peter et al., 1993 [PubMed 7905859]). See also SLC18A1 (MIM 193002).[supplied by OMIM, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:117241093-117279430
Strand Forward strand
Band q25.3
Transcripts
ENST00000298472 ENSP00000298472
ENST00000497497
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005275 amine transmembrane transporter activity
GO:0005515 protein binding
GO:0008144 drug binding
GO:0008504 monoamine transmembrane transporter activity
GO:0015222 serotonin transmembrane transporter activity
GO:0019899 enzyme binding
GO:0022857 transmembrane transporter activity
GO:0031072 heat shock protein binding
Biological Process
GO:0001975 response to amphetamine
GO:0006836 neurotransmitter transport
GO:0006837 serotonin transport
GO:0007268 synaptic transmission
GO:0007269 neurotransmitter secretion
GO:0007568 aging
GO:0007626 locomotory behavior
GO:0009635 response to herbicide
GO:0009636 response to toxic substance
GO:0009791 post-embryonic development
GO:0010038 response to metal ion
GO:0010043 response to zinc ion
GO:0015844 monoamine transport
GO:0016265 death
GO:0030073 insulin secretion
GO:0032456 endocytic recycling
GO:0035690 cellular response to drug
GO:0042220 response to cocaine
GO:0042493 response to drug
GO:0042593 glucose homeostasis
GO:0042594 response to starvation
GO:0051412 response to corticosterone
GO:0051589 negative regulation of neurotransmitter transport
GO:0055085 transmembrane transport
GO:0071242 cellular response to ammonium ion
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0008021 synaptic vesicle
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030672 synaptic vesicle membrane
GO:0031045 dense core granule
GO:0042995 cell projection
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043195 terminal bouton
GO:0043679 axon terminus
GO:0044297 cell body
GO:0070083 clathrin-sculpted monoamine transport vesicle membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Neuronal System pathway
Serotonin Neurotransmitter Release Cycle pathway
Norepinephrine Neurotransmitter Release Cycle pathway
Transmission across Chemical Synapses pathway
Neurotransmitter Release Cycle pathway
Na+/Cl- dependent neurotransmitter transporters pathway
Dopamine Neurotransmitter Release Cycle pathway
SLC-mediated transmembrane transport pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
KEGG
Parkinson's disease pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q05940
TrEMBL
UniProt Splice Variant
Entrez Gene 6571
UniGene Hs.596992 Hs.720642
RefSeq NM_003054
HUGO HGNC:10935
OMIM 193001
CCDS CCDS7599
HPRD
IMGT
EMBL AB044401 AK314997 AL391988 AL731557 BC108927 BC108928 CH471066 L09118 L14269 L23205 X71354
GenPept AAA59877 AAA61290 AAA91853 AAI08928 AAI08929 BAB19009 BAG37493 CAA50489 CAH70348 CAI14828 EAW49428 EAW49429
RNA Seq Atlas 6571