Homo sapiens Gene: GSTA4
Summary
InnateDB Gene IDBG-90859.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GSTA4
Gene Name glutathione S-transferase alpha 4
Synonyms GSTA4-4; GTA4;
Species Homo sapiens
Ensembl Gene ENSG00000170899
Encoded Proteins
glutathione S-transferase alpha 4
glutathione S-transferase alpha 4
glutathione S-transferase alpha 4
glutathione S-transferase alpha 4
glutathione S-transferase alpha 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, which are located in a cluster on chromosome 6, are highly related and encode enzymes with glutathione peroxidase activity that function in the detoxification of lipid peroxidation products. Reactive electrophiles produced by oxidative metabolism have been linked to a number of degenerative diseases including Parkinson's disease, Alzheimer's disease, cataract formation, and atherosclerosis. [provided by RefSeq, Jul 2008]
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, which are located in a cluster on chromosome 6, are highly related and encode enzymes with glutathione peroxidase activity that function in the detoxification of lipid peroxidation products. Reactive electrophiles produced by oxidative metabolism have been linked to a number of degenerative diseases including Parkinson\'s disease, Alzheimer\'s disease, cataract formation, and atherosclerosis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:52977948-52995378
Strand Reverse strand
Band p12.2
Transcripts
ENST00000370963 ENSP00000360002
ENST00000370960 ENSP00000359999
ENST00000370959 ENSP00000359998
ENST00000457564 ENSP00000394228
ENST00000477599
ENST00000486559
ENST00000541324 ENSP00000439439
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 3 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004364 glutathione transferase activity
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006749 glutathione metabolic process
GO:0006805 xenobiotic metabolic process
GO:0008152 metabolic process
GO:0044281 small molecule metabolic process
GO:1901687 glutathione derivative biosynthetic process
Cellular Component
GO:0005829 cytosol
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Glutathione conjugation pathway
Phase II conjugation pathway
Metabolism pathway
Biological oxidations pathway
KEGG
Glutathione metabolism pathway
Metabolism of xenobiotics by cytochrome P450 pathway
Drug metabolism pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.604053
RefSeq NM_001512 XM_005249035
HUGO
OMIM
CCDS CCDS4948
HPRD 06899
IMGT
EMBL
GenPept
RNA Seq Atlas