Version 5.4
Homo sapiens Gene: GSTA4
Summary
InnateDB Gene IDBG-90859.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GSTA4
Gene Name glutathione S-transferase alpha 4
Synonyms GSTA4-4; GTA4
Species Homo sapiens
Ensembl Gene ENSG00000170899
Encoded Proteins
IDBP-90861
glutathione S-transferase alpha 4
IDBP-90863
glutathione S-transferase alpha 4
IDBP-90865
glutathione S-transferase alpha 4
IDBP-381686
glutathione S-transferase alpha 4
IDBP-593419
glutathione S-transferase alpha 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, which are located in a cluster on chromosome 6, are highly related and encode enzymes with glutathione peroxidase activity that function in the detoxification of lipid peroxidation products. Reactive electrophiles produced by oxidative metabolism have been linked to a number of degenerative diseases including Parkinson's disease, Alzheimer's disease, cataract formation, and atherosclerosis. [provided by RefSeq, Jul 2008]
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, which are located in a cluster on chromosome 6, are highly related and encode enzymes with glutathione peroxidase activity that function in the detoxification of lipid peroxidation products. Reactive electrophiles produced by oxidative metabolism have been linked to a number of degenerative diseases including Parkinson\'s disease, Alzheimer\'s disease, cataract formation, and atherosclerosis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:52977948-52995378
Strand Reverse strand
Band p12.2
Transcripts
ENST00000370963 ENSP00000360002
ENST00000370960 ENSP00000359999
ENST00000370959 ENSP00000359998
ENST00000457564 ENSP00000394228
ENST00000477599
ENST00000486559
ENST00000541324 ENSP00000439439
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 3 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004364 glutathione transferase activity
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006749 glutathione metabolic process
GO:0006805 xenobiotic metabolic process
GO:0008152 metabolic process
GO:0044281 small molecule metabolic process
GO:1901687 glutathione derivative biosynthetic process
Cellular Component
GO:0005829 cytosol
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_6926
Glutathione conjugation pathway
REACT_6959
Phase II conjugation pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
KEGG
hsa00480
Glutathione metabolism pathway
hsa00980
Metabolism of xenobiotics by cytochrome P450 pathway
hsa00982
Drug metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q5JW88 Q6P4G1
UniProt Splice Variant
Entrez Gene 2941
UniGene Hs.604053
RefSeq NM_001512 XM_005249035
HUGO HGNC:4629
OMIM 605450
CCDS CCDS4948
HPRD 06899
IMGT
EMBL AL121969 AL162581 BC063439 CH471081 CR749474
GenPept AAH63439 CAH18304 EAX04393 EAX04395 EAX04396 EAX04397
RNA Seq Atlas 2941

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca