Homo sapiens Gene: TKTL1
Summary
InnateDB Gene IDBG-90970.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TKTL1
Gene Name transketolase-like 1
Synonyms TKR; TKT2;
Species Homo sapiens
Ensembl Gene ENSG00000007350
Encoded Proteins
transketolase-like 1
transketolase-like 1
transketolase-like 1
transketolase-like 1
transketolase-like 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a transketolase that acts as a homodimer and catalyzes the conversion of sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate to D-ribose 5-phosphate and D-xylulose 5-phosphate. This reaction links the pentose phosphate pathway with the glycolytic pathway. Variations in this gene may be the cause of Wernicke-Korsakoff syndrome. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome X:154295671-154330350
Strand Forward strand
Band q28
Transcripts
ENST00000369915 ENSP00000358931
ENST00000369912 ENSP00000358928
ENST00000439635 ENSP00000399763
ENST00000426989 ENSP00000401111
ENST00000426203 ENSP00000416552
ENST00000465168
ENST00000482044
ENST00000463884
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004802 transketolase activity
GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GO:0046872 metal ion binding
Biological Process
GO:0006007 glucose catabolic process
GO:0006772 thiamine metabolic process
GO:0008152 metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
Pentose phosphate pathway pathway
INOH
Pentose phosphate cycle pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.102866
RefSeq NM_001145933 NM_001145934 NM_012253
HUGO
OMIM
CCDS CCDS35448 CCDS55541
HPRD 02080
IMGT
EMBL
GenPept
RNA Seq Atlas