Version 5.4
Homo sapiens Gene: TKTL1
Summary
InnateDB Gene IDBG-90970.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TKTL1
Gene Name transketolase-like 1
Synonyms TKR; TKT2
Species Homo sapiens
Ensembl Gene ENSG00000007350
Encoded Proteins
IDBP-90972
transketolase-like 1
IDBP-90976
transketolase-like 1
IDBP-383344
transketolase-like 1
IDBP-383345
transketolase-like 1
IDBP-383350
transketolase-like 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a transketolase that acts as a homodimer and catalyzes the conversion of sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate to D-ribose 5-phosphate and D-xylulose 5-phosphate. This reaction links the pentose phosphate pathway with the glycolytic pathway. Variations in this gene may be the cause of Wernicke-Korsakoff syndrome. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome X:154295671-154330350
Strand Forward strand
Band q28
Transcripts
ENST00000369915 ENSP00000358931
ENST00000369912 ENSP00000358928
ENST00000439635 ENSP00000399763
ENST00000426989 ENSP00000401111
ENST00000426203 ENSP00000416552
ENST00000465168
ENST00000482044
ENST00000463884
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004802 transketolase activity
GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GO:0046872 metal ion binding
Biological Process
GO:0006007 glucose catabolic process
GO:0006772 thiamine metabolic process
GO:0008152 metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
hsa00030
Pentose phosphate pathway pathway
INOH
INOH website
Pentose phosphate cycle pathway
PID NCI
Cross-References
SwissProt P51854
TrEMBL
UniProt Splice Variant
Entrez Gene 8277
UniGene Hs.102866
RefSeq NM_001145934 NM_001145933 NM_012253
HUGO HGNC:11835
OMIM 300044
CCDS CCDS55541 CCDS35448
HPRD 02080
IMGT
EMBL AK292261 BC025382 BX664723 CH471172 U14622 X91817 X91818 Z49258
GenPept AAA21557 AAH25382 BAF84950 CAA62925 CAH69899 CAH69900 EAW72752
RNA Seq Atlas 8277

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca