Version 5.4
Homo sapiens Gene: BAG2
Summary
InnateDB Gene IDBG-91571.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BAG2
Gene Name BCL2-associated athanogene 2
Synonyms BAG-2; dJ417I1.2
Species Homo sapiens
Ensembl Gene ENSG00000112208
Encoded Proteins
IDBP-91573
BCL2-associated athanogene 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:57172326-57189833
Strand Forward strand
Band p12.1
Transcripts
ENST00000370693 ENSP00000359727
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 106 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 106 [view]
Protein-Protein 104 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0051087 chaperone binding
Biological Process
GO:0006457 protein folding
GO:0019538 protein metabolic process
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000042215
View Gene Order
ENSBTAG00000005355
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt O95816
TrEMBL
UniProt Splice Variant
Entrez Gene 9532
UniGene Hs.743450
RefSeq NM_004282
HUGO HGNC:938
OMIM 603882
CCDS CCDS4961
HPRD
IMGT
EMBL AF095192 AL031321 AL050287 AL136311 BC125039 CR533496
GenPept AAD16121 AAI25040 CAB43388 CAG38527 CAI20515 CAI21565
RNA Seq Atlas 9532

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca