InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RAB23

Summary

InnateDB Gene

IDBG-91614.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAB23

Gene Name

RAB23, member RAS oncogene family

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000112210

Encoded Proteins

IDBP-91616

RAB23, member RAS oncogene family

IDBP-483738

RAB23, member RAS oncogene family

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. It may be involved in small GTPase mediated signal transduction and intracellular protein transportation. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:57186992-57222314

Strand

Reverse strand

Band

p11.2

Transcripts

ENST00000317483	ENSP00000320413
ENST00000468148	ENSP00000417610

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005525	GTP binding

Biological Process

GO:0000045	autophagic vacuole assembly
GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0006913	nucleocytoplasmic transport
GO:0006968	cellular defense response
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0007399	nervous system development
GO:0008589	regulation of smoothened signaling pathway
GO:0015031	protein transport
GO:0021513	spinal cord dorsal/ventral patterning
GO:0042733	embryonic digit morphogenesis
GO:0042992	negative regulation of transcription factor import into nucleus
GO:0045861	negative regulation of proteolysis
GO:0097094	craniofacial suture morphogenesis

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005776	autophagic vacuole
GO:0005886	plasma membrane
GO:0010008	endosome membrane
GO:0016020	membrane
GO:0030670	phagocytic vesicle membrane
GO:0045335	phagocytic vesicle
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

Method

Confidence

Comments

ENSMUSG00000004768

View Gene Order

Ortholuge

SSD Ortholog

Ortholog supports species divergence

ENSBTAG00000005362

Not yet available

Ortholuge

SSD Ortholog

Ortholog supports species divergence

Pathways

NETPATH

NetPath_10

Hedgehog pathway

REACTOME

KEGG

hsa04340

Hedgehog signaling pathway pathway

INOH

PID BIOCARTA

PID NCI

hedgehog_glipathway

Hedgehog signaling events mediated by Gli proteins

Cross-References

SwissProt

Q9ULC3

TrEMBL

A0A024RD41

UniProt Splice Variant

Entrez Gene

51715

UniGene

Hs.555016 Hs.594199

RefSeq

NM_001278666 NM_001278667 NM_016277 XM_005249179 NM_001278668 NM_183227

HUGO

HGNC:14263

OMIM

606144

CCDS

CCDS4962

HPRD

05850

IMGT

EMBL

AB025427 AB034244 AF161486 AF498951 AK313796 AL031321 AY585189 BC015021 CH471081 CR749371

GenPept

AAF29101 AAH15021 AAM21099 AAT79492 BAA87324 BAB40309 BAG36532 CAH18224 CAI21564 EAX04476 EAX04478 EAX04479

RNA Seq Atlas

51715