Version 5.4
Homo sapiens Gene: RXRA
Summary
InnateDB Gene IDBG-91747.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RXRA
Gene Name retinoid X receptor, alpha
Synonyms NR2B1
Species Homo sapiens
Ensembl Gene ENSG00000186350
Encoded Proteins
IDBP-476267
retinoid X receptor, alpha
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20498053
RXRA controls innate inflammatory responses through the up-regulation of chemokine expression. Mice lacking RXRA in myeloid cells exhibit reduced levels of CCL6 and CCL9, impaired recruitment of leukocytes to sites of inflammation, and lower susceptibility to sepsis.
InnateDB Annotation from Orthologs
Summary
PMID 20498053
[Mus musculus] Rxra controls innate inflammatory responses through the up-regulation of chemokine expression. Mice lacking Rxra in myeloid cells exhibit reduced levels of CCL6 and CCL9, impaired recruitment of leukocytes to sites of inflammation, and lower susceptibility to sepsis.
Entrez Gene
Summary Retinoid X receptors (RXRs) and retinoic acid receptors (RARs), are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors exert their action by binding, as homodimers or heterodimers, to specific sequences in the promoters of target genes and regulating their transcription. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. [provided by RefSeq, Jul 2008]
Retinoid X receptors (RXRs) and retinoic acid receptors (RARs) are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors function as transcription factors by binding as homodimers or heterodimers to specific sequences in the promoters of target genes. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:134317098-134440585
Strand Forward strand
Band q34.2
Transcripts
ENST00000356384
ENST00000484822
ENST00000481739 ENSP00000419692
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 182 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 182 [view]
Protein-Protein 166 [view]
Protein-DNA 14 [view]
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0003708 retinoic acid receptor activity
GO:0003713 transcription coactivator activity
GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0004886 9-cis retinoic acid receptor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0019899 enzyme binding
GO:0031490 chromatin DNA binding
GO:0042809 vitamin D receptor binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0044323 retinoic acid-responsive element binding
GO:0046982 protein heterodimerization activity
GO:0070644 vitamin D response element binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001701 in utero embryonic development
GO:0001890 placenta development
GO:0001893 maternal placenta development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006766 vitamin metabolic process
GO:0007507 heart development
GO:0007566 embryo implantation
GO:0008203 cholesterol metabolic process
GO:0010467 gene expression
GO:0019048 modulation by virus of host morphology or physiology
GO:0032526 response to retinoic acid
GO:0035357 peroxisome proliferator activated receptor signaling pathway
GO:0043010 camera-type eye development
GO:0043401 steroid hormone mediated signaling pathway
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response (InnateDB)
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048384 retinoic acid receptor signaling pathway
GO:0051289 protein homotetramerization
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0055012 ventricular cardiac muscle cell differentiation
GO:0060038 cardiac muscle cell proliferation
GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
GO:0060687 regulation of branching involved in prostate gland morphogenesis
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000015846
View Gene Order
ENSBTAG00000017851
Not yet available
Pathways
NETPATH
NetPath_9
TNFalpha pathway
NetPath_15
IL3 pathway
REACTOME
REACT_116145
PPARA activates gene expression pathway
REACT_19241
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_11041
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol pathway
REACT_11048
Synthesis of bile acids and bile salts via 27-hydroxycholesterol pathway
REACT_11054
Synthesis of bile acids and bile salts pathway
REACT_11042
Recycling of bile acids and salts pathway
REACT_147904
Activation of gene expression by SREBF (SREBP) pathway
REACT_147797
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
REACT_11082
Import of palmitoyl-CoA into the mitochondrial matrix pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_12528
Regulation of pyruvate dehydrogenase (PDH) complex pathway
REACT_2071
Pyruvate metabolism pathway
REACT_13812
Endogenous sterols pathway
REACT_118659
RORA activates circadian gene expression pathway
REACT_111118
BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway
REACT_118789
REV-ERBA represses gene expression pathway
REACT_24941
Circadian Clock pathway
REACT_15525
Nuclear Receptor transcription pathway pathway
REACT_118713
YAP1- and WWTR1 (TAZ)-stimulated gene expression pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_27161
Transcriptional regulation of white adipocyte differentiation pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_200751
Organelle biogenesis and maintenance pathway
REACT_111045
Developmental Biology pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_1046
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
REACT_11040
Bile acid and bile salt metabolism pathway
REACT_200788
Mitochondrial biogenesis pathway
REACT_13567
Cytochrome P450 - arranged by substrate type pathway
REACT_267716
Orphan transporters pathway
REACT_200608
Transcriptional activation of mitochondrial biogenesis pathway
REACT_111083
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
REACT_71
Gene Expression pathway
REACT_13705
Phase 1 - Functionalization of compounds pathway
KEGG
hsa05223
Non-small cell lung cancer pathway
hsa05216
Thyroid cancer pathway
hsa05222
Small cell lung cancer pathway
hsa03320
PPAR signaling pathway pathway
hsa04920
Adipocytokine signaling pathway pathway
hsa05200
Pathways in cancer pathway
hsa04976
Bile secretion pathway
hsa05160
Hepatitis C pathway
INOH
PID NCI
rxr_vdr_pathway
RXR and RAR heterodimerization with other nuclear receptor
retinoic_acid_pathway
Retinoic acid receptors-mediated signaling
Cross-References
SwissProt P19793
TrEMBL B3KY83 F1D8Q5 Q6P3U7
UniProt Splice Variant
Entrez Gene 6256
UniGene Hs.644632 Hs.649320
RefSeq NM_001291920 NM_002957
HUGO HGNC:10477
OMIM 180245
CCDS CCDS35172
HPRD
IMGT
EMBL AB307705 AC156789 AK131192 AL354796 AL669970 AL683798 BC063827 BC110998 CH471090 DQ303444 HQ692843 X52773
GenPept AAH63827 AAI10999 ABB96254 ADZ17354 BAG54745 BAH02296 CAA36982 CAH70571 CAM45733 EAW88123 EAW88124
RNA Seq Atlas 6256

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca