Version 5.4
Homo sapiens Gene: DMBT1
Summary
InnateDB Gene IDBG-91946.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DMBT1
Gene Name deleted in malignant brain tumors 1
Synonyms GP340; muclin
Species Homo sapiens
Ensembl Gene ENSG00000187908
Encoded Proteins
IDBP-91950
deleted in malignant brain tumors 1
IDBP-91952
deleted in malignant brain tumors 1
IDBP-91958
deleted in malignant brain tumors 1
IDBP-91964
deleted in malignant brain tumors 1
IDBP-91966
deleted in malignant brain tumors 1
IDBP-91972
deleted in malignant brain tumors 1
IDBP-91976
deleted in malignant brain tumors 1
IDBP-810130
deleted in malignant brain tumors 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20418254
DMBT1 encodes alternatively spliced proteins involved in mucosal innate immunity and two other molecules, a glycoprotein with a molecular mass of 340 kDa (GP340) and salivary agglutinin (DMBT1(SAG)). GP340 is secreted into broncho-alveolar surface lining fluid whereas DMBT1(SAG) is present in the saliva. Both interact with and agglutinate several Gram-negative and Gram-positive bacteria, as well as some viruses.
Entrez Gene
Summary Loss of sequences from human chromosome 10q has been associated with the progression of human cancers. The gene DMBT1 was originally isolated based on its deletion in a medulloblastoma cell line. DMBT1 is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized. The DMBT1 protein is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID). Transcript variant 2 (8.0 kb) has been shown to bind surfactant protein D independently of carbohydrate recognition. This indicates that DMBT1 may not be a classical tumor supressor gene, but rather play a role in the interaction of tumor cells and the immune system. [provided by RefSeq, Jul 2008]
Loss of sequences from human chromosome 10q has been associated with the progression of human cancers. The gene DMBT1 was originally isolated based on its deletion in a medulloblastoma cell line. DMBT1 is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized. The DMBT1 protein is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID). Transcript variant 2 (8.0 kb) has been shown to bind surfactant protein D independently of carbohydrate recognition. This indicates that DMBT1 may not be a classical tumor supressor gene, but rather play a role in the interaction of tumor cells and the immune system. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:122560665-122643736
Strand Forward strand
Band q26.13
Transcripts
ENST00000368956 ENSP00000357952
ENST00000368955 ENSP00000357951
ENST00000338354 ENSP00000342210
ENST00000344338 ENSP00000343175
ENST00000330163 ENSP00000327747
ENST00000359586 ENSP00000352593
ENST00000368909 ENSP00000357905
ENST00000619379 ENSP00000484603
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005044 scavenger receptor activity
GO:0005515 protein binding
GO:0008329 signaling pattern recognition receptor activity
GO:0035375 zymogen binding
GO:0048306 calcium-dependent protein binding
Biological Process
GO:0001824 blastocyst development
GO:0001833 inner cell mass cell proliferation
GO:0002221 pattern recognition receptor signaling pathway
GO:0006898 receptor-mediated endocytosis
GO:0015031 protein transport
GO:0016032 viral process
GO:0030855 epithelial cell differentiation
GO:0030858 positive regulation of epithelial cell differentiation
GO:0043152 induction of bacterial agglutination
GO:0045087 innate immune response (InnateDB)
GO:0051607 defense response to virus
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0019898 extrinsic component of membrane
GO:0030670 phagocytic vesicle membrane
GO:0042589 zymogen granule membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000047517
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
hsa04970
Salivary secretion pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_004406 NM_007329 NM_017579 XM_006717670 XM_006717671 XM_006717673 XM_006717674 XM_006717676 XM_006717678
HUGO
OMIM
CCDS CCDS44490 CCDS44491 CCDS44492
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca