Version 5.4
Homo sapiens Gene: ABCB5
Summary
InnateDB Gene IDBG-9209.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ABCB5
Gene Name ATP-binding cassette, sub-family B (MDR/TAP), member 5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000004846
Encoded Proteins
IDBP-9215
ATP-binding cassette, sub-family B (MDR/TAP), member 5
IDBP-294994
ATP-binding cassette, sub-family B (MDR/TAP), member 5
IDBP-294992
ATP-binding cassette, sub-family B (MDR/TAP), member 5
IDBP-367192
ATP-binding cassette, sub-family B (MDR/TAP), member 5
IDBP-367194
ATP-binding cassette, sub-family B (MDR/TAP), member 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary ABCB5 belongs to the ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins. These proteins participate in ATP-dependent transmembrane transport of structurally diverse molecules ranging from small ions, sugars, and peptides to more complex organic molecules (Chen et al., 2005 [PubMed 15760339]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:20615207-20777038
Strand Forward strand
Band p21.1
Transcripts
ENST00000258738 ENSP00000258738
ENST00000404938 ENSP00000384881
ENST00000406935 ENSP00000383899
ENST00000443026 ENSP00000406730
ENST00000441315 ENSP00000398692
ENST00000477094
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005524 ATP binding
GO:0015562 efflux transmembrane transporter activity
GO:0016887 ATPase activity
GO:0042626 ATPase activity, coupled to transmembrane movement of substances
Biological Process
GO:0002481 antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
GO:0002485 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
GO:0002489 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent
GO:0002591 positive regulation of antigen processing and presentation of peptide antigen via MHC class I
GO:0006200 ATP catabolic process
GO:0006810 transport
GO:0042391 regulation of membrane potential
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000072791
View Gene Order
ENSBTAG00000002595
Not yet available
Pathways
NETPATH
REACTOME
REACT_15480
ABC-family proteins mediated transport pathway
REACT_15518
Transmembrane transport of small molecules pathway
KEGG
hsa02010
ABC transporters pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.404102
RefSeq NM_001163941 NM_001163942 NM_001163993 NM_178559
HUGO
OMIM
CCDS CCDS5371 CCDS55090 CCDS55091 CCDS55092
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca