Homo sapiens Gene: LHX3
Summary
InnateDB Gene IDBG-92191.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LHX3
Gene Name LIM homeobox 3
Synonyms CPHD3; LIM3; M2-LHX3;
Species Homo sapiens
Ensembl Gene ENSG00000107187
Encoded Proteins
LIM homeobox 3
LIM homeobox 3
LIM homeobox 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member a large protein family which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor that is required for pituitary development and motor neuron specification. Mutations in this gene cause combined pituitary hormone deficiency 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:136196250-136205109
Strand Reverse strand
Band q34.3
Transcripts
ENST00000371748 ENSP00000360813
ENST00000371746 ENSP00000360811
ENST00000619587 ENSP00000483080
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001076 RNA polymerase II transcription factor binding transcription factor activity
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001890 placenta development
GO:0006366 transcription from RNA polymerase II promoter
GO:0008045 motor neuron axon guidance
GO:0009887 organ morphogenesis
GO:0009953 dorsal/ventral pattern formation
GO:0021520 spinal cord motor neuron cell fate specification
GO:0021521 ventral spinal cord interneuron specification
GO:0021526 medial motor column neuron differentiation
GO:0021527 spinal cord association neuron differentiation
GO:0021983 pituitary gland development
GO:0030154 cell differentiation
GO:0030324 lung development
GO:0043066 negative regulation of apoptotic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048839 inner ear development
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005667 transcription factor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt Q9UBR4
TrEMBL F1T0D5
UniProt Splice Variant
Entrez Gene 8022
UniGene
RefSeq NM_178138 NM_014564 XM_005263410
HUGO HGNC:6595
OMIM 600577
CCDS CCDS6994 CCDS6995
HPRD 02783
IMGT
EMBL AB593062 AB593063 AB593067 AF096169 AF156888 AF156889 AF214637 AF367085 AF367086 AF367087 AF367088 AF367089 AH008761 AL138781 CH471090
GenPept AAF17291 AAF17292 AAF26412 AAF36808 AAF36809 AAL26314 BAJ84009 BAJ84010 BAJ84014 CAI16878 CAI16879 EAW88205 EAW88206
RNA Seq Atlas 8022