InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SPTB

Summary

InnateDB Gene

IDBG-9231.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPTB

Gene Name

spectrin, beta, erythrocytic

Synonyms

EL3; HS2; HSPTB1; SPH2

Species

Homo sapiens

Ensembl Gene

ENSG00000070182

Encoded Proteins

IDBP-9241

spectrin, beta, erythrocytic

IDBP-9245

spectrin, beta, erythrocytic

IDBP-9247

spectrin, beta, erythrocytic

IDBP-604280

spectrin, beta, erythrocytic

IDBP-604281

spectrin, beta, erythrocytic

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This locus encodes a member of the spectrin gene family. Spectrin proteins, along with ankyrin, play a role in cell membrane organization and stability. The protein encoded by this locus functions in stability of erythrocyte membranes, and mutations in this gene have been associated with spherocytosis type 2, hereditary elliptocytosis, and neonatal hemolytic anemia. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:64746283-64879883

Strand

Reverse strand

Band

q23.3

Transcripts

ENST00000342835
ENST00000389722	ENSP00000374372
ENST00000389720	ENSP00000374370
ENST00000389721	ENSP00000374371
ENST00000553938	ENSP00000451324
ENST00000556227
ENST00000556626	ENSP00000451752
ENST00000542694

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005200	structural constituent of cytoskeleton
GO:0005515	protein binding
GO:0030506	ankyrin binding
GO:0046982	protein heterodimerization activity
GO:0051015	actin filament binding

Biological Process

GO:0006779	porphyrin-containing compound biosynthetic process
GO:0007009	plasma membrane organization
GO:0007411	axon guidance
GO:0030097	hemopoiesis
GO:0051693	actin filament capping

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0008091	spectrin
GO:0009986	cell surface
GO:0014731	spectrin-associated cytoskeleton
GO:0015629	actin cytoskeleton
GO:0016020	membrane
GO:0030863	cortical cytoskeleton
GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane
GO:0043234	protein complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000021061

View Gene Order

ENSBTAG00000004732

Not yet available

Pathways

NETPATH

REACTOME

REACT_22266

Interaction between L1 and Ankyrins pathway

REACT_22205

L1CAM interactions pathway

REACT_18334

NCAM signaling for neurite out-growth pathway

REACT_111045

Developmental Biology pathway

REACT_18266

Axon guidance pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

P11277

TrEMBL

H0YJE6 O14725 O14726 Q59FP5 Q71VF8 Q71VF9 Q71VG0 Q71VG1 Q71VG2

UniProt Splice Variant

Entrez Gene

6710

UniGene

Hs.417303

RefSeq

NM_000347 NM_001024858 XM_005268023 XM_006720241

HUGO

HGNC:11274

OMIM

182870

CCDS

CCDS32099 CCDS32100

HPRD

IMGT

EMBL

AB209415 AF013172 AF013173 AF013174 AF013178 AF013179 AF013180 AF013181 AF013182 AF013183 AF013184 AF013185 AF013186 AF013187 AL121774 AL135745 J05500 M18054 M37884 M37885 M57948 X59510 X59511

GenPept

AAA60571 AAA60572 AAA60578 AAA60579 AAA63259 AAC02786 AAC02787 AAC02788 AAC02790 AAC02791 AAC02792 AAC02793 BAD92652 CAA42097 CAA42098

RNA Seq Atlas

6710