Homo sapiens Gene: NAT2
Summary
InnateDB Gene IDBG-9298.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NAT2
Gene Name N-acetyltransferase 2 (arylamine N-acetyltransferase)
Synonyms AAC2; NAT-2; PNAT;
Species Homo sapiens
Ensembl Gene ENSG00000156006
Encoded Proteins
N-acetyltransferase 2 (arylamine N-acetyltransferase)
N-acetyltransferase 2 (arylamine N-acetyltransferase)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and drug toxicity. A second arylamine N-acetyltransferase gene (NAT1) is located near this gene (NAT2). [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:18391245-18401218
Strand Forward strand
Band p22
Transcripts
ENST00000286479 ENSP00000286479
ENST00000520116 ENSP00000428416
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004060 arylamine N-acetyltransferase activity
GO:0016407 acetyltransferase activity
Biological Process
GO:0006805 xenobiotic metabolic process
GO:0008152 metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005829 cytosol
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Phase II conjugation pathway
Acetylation pathway
Metabolism pathway
Biological oxidations pathway
KEGG
Caffeine metabolism pathway
Drug metabolism pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL E7EWF9
UniProt Splice Variant
Entrez Gene 10
UniGene Hs.2
RefSeq NM_000015
HUGO HGNC:7646
OMIM 612182
CCDS CCDS6008
HPRD 02000
IMGT
EMBL AC025062 AC120051
GenPept
RNA Seq Atlas 10