Version 5.4
Homo sapiens Gene: NAT2
Summary
InnateDB Gene IDBG-9298.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NAT2
Gene Name N-acetyltransferase 2 (arylamine N-acetyltransferase)
Synonyms AAC2; NAT-2; PNAT
Species Homo sapiens
Ensembl Gene ENSG00000156006
Encoded Proteins
IDBP-9300
N-acetyltransferase 2 (arylamine N-acetyltransferase)
IDBP-479727
N-acetyltransferase 2 (arylamine N-acetyltransferase)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and drug toxicity. A second arylamine N-acetyltransferase gene (NAT1) is located near this gene (NAT2). [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:18391245-18401218
Strand Forward strand
Band p22
Transcripts
ENST00000286479 ENSP00000286479
ENST00000520116 ENSP00000428416
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004060 arylamine N-acetyltransferase activity
GO:0016407 acetyltransferase activity
Biological Process
GO:0006805 xenobiotic metabolic process
GO:0008152 metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005829 cytosol
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_6732
Acetylation pathway
REACT_6959
Phase II conjugation pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
KEGG
hsa00232
Caffeine metabolism pathway
hsa00983
Drug metabolism pathway
INOH
PID NCI
Cross-References
SwissProt P11245
TrEMBL A4Z6T7 E7EWF9 Q400I7
UniProt Splice Variant
Entrez Gene 10
UniGene Hs.2
RefSeq NM_000015
HUGO HGNC:7646
OMIM 612182
CCDS CCDS6008
HPRD
IMGT
EMBL AC025062 AC120051 AF042740 AF055874 AF055875 AF320309 AF348074 AF348075 AJ581144 AJ581145 AY230251 AY230252 AY331807 BC015878 BC067218 CR407631 D10870 D10871 D10872 D90040 D90042 DQ305496 DQ305497 DQ305498 DQ305499 DQ305500 DQ305501 DQ305502 DQ305503 DQ305504 DQ305505 DQ305506 DQ305507 DQ305508 DQ305509 DQ305510 DQ305511 DQ305512 DQ305513 DQ305514 DQ305515 DQ305516 DQ305517 DQ305518 DQ305519 DQ305520 DQ305521 DQ305522 DQ305523 DQ305524 DQ305525 DQ305526 DQ305527 DQ305528 DQ305529 DQ305530 DQ305531 DQ305532 DQ305533 DQ305534 DQ305535 DQ305536 DQ305537 DQ305538 DQ305539 DQ305540 DQ305541 DQ305542 DQ305543 DQ305544 DQ305545 DQ305546 DQ305547 DQ305548 DQ305549 DQ305550 DQ305551 DQ305552 DQ305553 DQ305554 DQ305555 DQ305556 DQ305557 DQ305558 DQ305559 DQ305560 DQ305561 DQ305562 DQ305563 DQ305564 DQ305565 DQ305566 DQ305567 DQ305568 DQ305569 DQ305570 DQ305571 DQ305572 DQ305573 DQ305574 DQ305575 DQ305576 DQ305577 DQ305578 DQ305579 DQ305580 DQ305581 DQ305582 DQ305583 DQ305584 DQ305585 DQ305586 DQ305587 DQ305588 DQ305589 DQ305590 DQ305591 DQ305592 DQ305593 DQ305594 DQ305595 DQ305596 DQ305597 DQ305598 DQ305599 DQ305600 DQ305601 DQ305602 DQ305603 DQ305604 DQ305605 DQ305606 DQ305607 DQ305608 DQ305609 DQ305610 DQ305611 DQ305612 DQ305613 DQ305614 DQ305615 DQ305616 DQ305617 DQ305618 DQ305619 DQ305620 DQ305621 DQ305622 DQ305623 DQ305624 DQ305625 DQ305626 DQ305627 DQ305628 DQ305629 DQ305630 DQ305631 DQ305632 DQ305633 DQ305634 DQ305635 DQ305636 DQ305637 DQ305638 DQ305639 DQ305640 DQ305641 DQ305642 DQ305643 DQ305644 DQ305645 DQ305646 DQ305647 DQ305648 DQ305649 DQ305650 DQ305651 DQ305652 DQ305653 DQ305654 DQ305655 DQ472738 DQ472742 DQ472746 DQ472749 DQ472754 DQ472755 DQ472768 DQ472778 DQ472793 DQ472796 DQ472798 DQ472804 DQ472808 DQ472812 DQ472813 DQ472816 DQ472820 DQ472832 DQ472864 DQ472868 DQ472869 DQ472873 DQ472881 DQ472892 DQ472906 DQ472914 DQ472929 DQ472941 DQ472949 DQ472951 DQ472952 DQ472961 DQ472964 DQ472980 DQ472996 DQ473006 DQ473012 DQ473015 DQ473016 DQ473026 DQ473027 DQ473030 DQ473031 DQ473034 DQ473039 DQ473044 DQ473095 DQ473107 DQ473111 DQ473112 DQ473113 DQ473114 DQ473115 DQ473130 DQ473134 DQ473136 DQ473139 DQ473143 DQ473144 DQ473146 DQ473149 DQ473152 DQ473153 DQ473154 DQ473155 DQ473159 DQ473163 DQ473187 DQ473208 DQ473212 DQ473213 DQ473216 DQ473217 DQ473219 DQ473230 DQ473233 DQ473235 DQ473236 DQ473238 DQ473256 DQ473258 DQ473261 DQ473262 DQ473264 DQ904040 DQ904041 DQ904042 DQ904043 DQ904044 DQ904046 DQ904048 DQ904050 DQ904053 DQ904080 DQ904082 DQ904084 DQ904086 DQ904088 DQ904169 DQ904171 DQ904173 DQ904175 DQ904177 DQ904179 DQ904181 DQ904183 DQ904185 DQ904187 DQ904220 M75163 U23052 U23434 U53473 X14672
GenPept AAA59906 AAA64584 AAA64585 AAA98976 AAC03773 AAC14117 AAC14118 AAG34181 AAH15878 AAH67218 AAK51710 AAK51711 AAO73561 AAO73562 AAP81164 ABC26032 ABC26033 ABC26034 ABC26035 ABC26036 ABC26037 ABC26038 ABC26039 ABC26040 ABC26041 ABC26042 ABC26043 ABC26044 ABC26045 ABC26046 ABC26047 ABC26048 ABC26049 ABC26050 ABC26051 ABC26052 ABC26053 ABC26054 ABC26055 ABC26056 ABC26057 ABC26058 ABC26059 ABC26060 ABC26061 ABC26062 ABC26063 ABC26064 ABC26065 ABC26066 ABC26067 ABC26068 ABC26069 ABC26070 ABC26071 ABC26072 ABC26073 ABC26074 ABC26075 ABC26076 ABC26077 ABC26078 ABC26079 ABC26080 ABC26081 ABC26082 ABC26083 ABC26084 ABC26085 ABC26086 ABC26087 ABC26088 ABC26089 ABC26090 ABC26091 ABC26092 ABC26093 ABC26094 ABC26095 ABC26096 ABC26097 ABC26098 ABC26099 ABC26100 ABC26101 ABC26102 ABC26103 ABC26104 ABC26105 ABC26106 ABC26107 ABC26108 ABC26109 ABC26110 ABC26111 ABC26112 ABC26113 ABC26114 ABC26115 ABC26116 ABC26117 ABC26118 ABC26119 ABC26120 ABC26121 ABC26122 ABC26123 ABC26124 ABC26125 ABC26126 ABC26127 ABC26128 ABC26129 ABC26130 ABC26131 ABC26132 ABC26133 ABC26134 ABC26135 ABC26136 ABC26137 ABC26138 ABC26139 ABC26140 ABC26141 ABC26142 ABC26143 ABC26144 ABC26145 ABC26146 ABC26147 ABC26148 ABC26149 ABC26150 ABC26151 ABC26152 ABC26153 ABC26154 ABC26155 ABC26156 ABC26157 ABC26158 ABC26159 ABC26160 ABC26161 ABC26162 ABC26163 ABC26164 ABC26165 ABC26166 ABC26167 ABC26168 ABC26169 ABC26170 ABC26171 ABC26172 ABC26173 ABC26174 ABC26175 ABC26176 ABC26177 ABC26178 ABC26179 ABC26180 ABC26181 ABC26182 ABC26183 ABC26184 ABC26185 ABC26186 ABC26187 ABC26188 ABC26189 ABC26190 ABC26191 ABF01136 ABF01140 ABF01144 ABF01147 ABF01152 ABF01153 ABF01166 ABF01176 ABF01191 ABF01194 ABF01196 ABF01202 ABF01206 ABF01210 ABF01211 ABF01214 ABF01218 ABF01230 ABF01262 ABF01266 ABF01267 ABF01271 ABF01279 ABF01290 ABF01304 ABF01312 ABF01327 ABF01339 ABF01347 ABF01349 ABF01350 ABF01359 ABF01362 ABF01378 ABF01394 ABF01404 ABF01410 ABF01413 ABF01414 ABF01424 ABF01425 ABF01428 ABF01429 ABF01432 ABF01437 ABF01442 ABF01493 ABF01505 ABF01509 ABF01510 ABF01511 ABF01512 ABF01513 ABF01528 ABF01532 ABF01534 ABF01537 ABF01541 ABF01542 ABF01544 ABF01547 ABF01550 ABF01551 ABF01552 ABF01553 ABF01557 ABF01561 ABF01585 ABF01606 ABF01610 ABF01611 ABF01614 ABF01615 ABF01617 ABF01628 ABF01631 ABF01633 ABF01634 ABF01636 ABF01654 ABF01656 ABF01659 ABF01660 ABF01662 ABK34557 ABK34558 ABK34559 ABK34560 ABK34561 ABK34563 ABK34565 ABK34567 ABK34570 ABK34597 ABK34599 ABK34601 ABK34603 ABK34605 ABK34686 ABK34688 ABK34690 ABK34692 ABK34694 ABK34696 ABK34698 ABK34700 ABK34702 ABK34704 ABK34737 BAA01640 BAA01641 BAA01642 BAA14094 BAA14096 CAA32802 CAE46171 CAE46172 CAG28559
RNA Seq Atlas 10

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca