InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MYO6

Summary

InnateDB Gene

IDBG-93156.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYO6

Gene Name

myosin VI

Synonyms

DFNA22; DFNB37

Species

Homo sapiens

Ensembl Gene

ENSG00000196586

Encoded Proteins

IDBP-93158

myosin VI

IDBP-93160

myosin VI

IDBP-93164

myosin VI

IDBP-93166

myosin VI

IDBP-384267

myosin VI

IDBP-812942

myosin VI

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein involved intracellular vesicle and organelle transport, especially in the hair cell of the inner ear. Mutations in this gene have been found in patients with non-syndromic autosomal dominant and recessive hearing loss. [provided by RefSeq, Jul 2008]
This gene encodes a reverse-direction motor protein that moves toward the minus end of actin filaments and plays a role in intracellular vesicle and organelle transport. The protein consists of a motor domain containing an ATP- and an actin-binding site and a globular tail which interacts with other proteins. This protein maintains the structural integrity of inner ear hair cells and mutations in this gene cause non-syndromic autosomal dominant and recessive hearing loss. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:75749192-75919537

Strand

Forward strand

Band

q14.1

Transcripts

ENST00000369985	ENSP00000359002
ENST00000369981	ENSP00000358998
ENST00000369977	ENSP00000358994
ENST00000369975	ENSP00000358992
ENST00000430435	ENSP00000399406
ENST00000462633
ENST00000615563	ENSP00000478013

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	48 [view]
Protein-Protein	48 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003774	motor activity
GO:0003779	actin binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0043531	ADP binding
GO:0051015	actin filament binding
GO:0060001	minus-end directed microfilament motor activity

Biological Process

GO:0006605	protein targeting
GO:0006886	intracellular protein transport
GO:0006897	endocytosis
GO:0007268	synaptic transmission
GO:0007416	synapse assembly
GO:0007605	sensory perception of sound
GO:0007626	locomotory behavior
GO:0008152	metabolic process
GO:0014047	glutamate secretion
GO:0016358	dendrite development
GO:0030048	actin filament-based movement
GO:0030330	DNA damage response, signal transduction by p53 class mediator
GO:0042472	inner ear morphogenesis
GO:0042491	auditory receptor cell differentiation
GO:0042493	response to drug
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048167	regulation of synaptic plasticity
GO:0048839	inner ear development
GO:0051046	regulation of secretion
GO:0061024	membrane organization
GO:0071257	cellular response to electrical stimulus

Cellular Component

GO:0001726	ruffle
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005765	lysosomal membrane
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005902	microvillus
GO:0005905	coated pit
GO:0005938	cell cortex
GO:0012506	vesicle membrane
GO:0016020	membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0016459	myosin complex
GO:0016461	unconventional myosin complex
GO:0016591	DNA-directed RNA polymerase II, holoenzyme
GO:0030139	endocytic vesicle
GO:0030424	axon
GO:0030665	clathrin-coated vesicle membrane
GO:0031941	filamentous actin
GO:0031965	nuclear membrane
GO:0032587	ruffle membrane
GO:0043025	neuronal cell body
GO:0043231	intracellular membrane-bounded organelle
GO:0043234	protein complex
GO:0045177	apical part of cell
GO:0045334	clathrin-coated endocytic vesicle
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular vesicular exosome