Version 5.4
Homo sapiens Gene: RAP1GAP
Summary
InnateDB Gene IDBG-93263.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAP1GAP
Gene Name RAP1 GTPase activating protein
Synonyms RAP1GA1; RAP1GAP1; RAP1GAPII; RAPGAP
Species Homo sapiens
Ensembl Gene ENSG00000076864
Encoded Proteins
IDBP-93265
RAP1 GTPase activating protein
IDBP-93269
RAP1 GTPase activating protein
IDBP-93273
RAP1 GTPase activating protein
IDBP-93275
RAP1 GTPase activating protein
IDBP-93279
RAP1 GTPase activating protein
IDBP-374275
RAP1 GTPase activating protein
IDBP-585075
RAP1 GTPase activating protein
IDBP-591188
RAP1 GTPase activating protein
IDBP-589014
RAP1 GTPase activating protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:21596215-21669363
Strand Reverse strand
Band p36.12
Transcripts
ENST00000317967 ENSP00000315420
ENST00000374765 ENSP00000363897
ENST00000374763 ENSP00000363895
ENST00000374761 ENSP00000363893
ENST00000290101 ENSP00000290101
ENST00000374757
ENST00000447293 ENSP00000392717
ENST00000471600 ENSP00000431364
ENST00000495204 ENSP00000434033
ENST00000482984
ENST00000464457
ENST00000542643 ENSP00000441661
ENST00000611549
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 25 [view]
Protein-Protein 24 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0017016 Ras GTPase binding
GO:0030695 GTPase regulator activity
GO:0042803 protein homodimerization activity
GO:0046582 Rap GTPase activator activity
Biological Process
GO:0006184 GTP catabolic process
GO:0007165 signal transduction
GO:0032318 regulation of Ras GTPase activity
GO:0032854 positive regulation of Rap GTPase activity
GO:0043547 positive regulation of GTPase activity
GO:0050790 regulation of catalytic activity
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0000139 Golgi membrane
GO:0005829 cytosol
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000041351
View Gene Order
ENSBTAG00000008952
Not yet available
Pathways
NETPATH
NetPath_23
TSH pathway
REACTOME
REACT_23898
Rap1 signalling pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.148178
RefSeq NM_001145657 NM_001145658 NM_002885 XM_005245955 XM_005245956 XM_006710804 XM_006710806 XM_006710807
HUGO
OMIM
CCDS CCDS218 CCDS53276 CCDS53277
HPRD 02609
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca