Version 5.4
Homo sapiens Gene: BNIP3
Summary
InnateDB Gene IDBG-93314.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BNIP3
Gene Name BCL2/adenovirus E1B 19kDa interacting protein 3
Synonyms NIP3
Species Homo sapiens
Ensembl Gene ENSG00000176171
Encoded Proteins
IDBP-93316
BCL2/adenovirus E1B 19kDa interacting protein 3
IDBP-588200
BCL2/adenovirus E1B 19kDa interacting protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 26253785
[Mus musculus] Mitophagy-inducing proteins Bnip3 and Bnip3l play a regulatory role in the generation of robust natural killer cell memory.
Entrez Gene
Summary This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. This protein contains a BH3 domain and a transmembrane domain, which have been associated with pro-apoptotic function. The dimeric mitochondrial protein encoded by this gene is known to induce apoptosis, even in the presence of BCL2. [provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:131966455-131981931
Strand Reverse strand
Band q26.3
Transcripts
ENST00000368636 ENSP00000357625
ENST00000540159 ENSP00000446145
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 27 [view]
Protein-Protein 27 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046982 protein heterodimerization activity
GO:0051020 GTPase binding
Biological Process
GO:0001666 response to hypoxia
GO:0006915 apoptotic process
GO:0008219 cell death
GO:0008626 granzyme-mediated apoptotic signaling pathway
GO:0010508 positive regulation of autophagy
GO:0010637 negative regulation of mitochondrial fusion
GO:0016032 viral process
GO:0035694 mitochondrial protein catabolic process
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043068 positive regulation of programmed cell death
GO:0043243 positive regulation of protein complex disassembly
GO:0043653 mitochondrial fragmentation involved in apoptotic process
GO:0045837 negative regulation of membrane potential
GO:0046902 regulation of mitochondrial membrane permeability
GO:0048102 autophagic cell death
GO:0050873 brown fat cell differentiation
GO:0051402 neuron apoptotic process
GO:0051607 defense response to virus
GO:0055093 response to hyperoxia
GO:0070301 cellular response to hydrogen peroxide
GO:0071260 cellular response to mechanical stimulus
GO:0071279 cellular response to cobalt ion
GO:0071456 cellular response to hypoxia
GO:0072593 reactive oxygen species metabolic process
GO:0090141 positive regulation of mitochondrial fission
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:0097193 intrinsic apoptotic signaling pathway
GO:0097345 mitochondrial outer membrane permeabilization
GO:1990144 intrinsic apoptotic signaling pathway in response to hypoxia
Cellular Component
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005740 mitochondrial envelope
GO:0005741 mitochondrial outer membrane
GO:0005783 endoplasmic reticulum
GO:0016021 integral component of membrane
GO:0030425 dendrite
GO:0031307 integral component of mitochondrial outer membrane
GO:0031966 mitochondrial membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000078566
View Gene Order
ENSBTAG00000017804
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
mtor_4pathway
mTOR signaling pathway
hif1_tfpathway
HIF-1-alpha transcription factor network
Cross-References
SwissProt
TrEMBL B4DHJ7
UniProt Splice Variant
Entrez Gene 664
UniGene Hs.678752
RefSeq NM_004052
HUGO HGNC:1084
OMIM 603293
CCDS CCDS7663
HPRD 04482
IMGT
EMBL AK295136 AL162274
GenPept BAG58159
RNA Seq Atlas 664

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca