Version 5.4
Homo sapiens Gene: IRAK1BP1
Summary
InnateDB Gene IDBG-93345.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IRAK1BP1
Gene Name interleukin-1 receptor-associated kinase 1 binding protein 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000146243
Encoded Proteins
IDBP-93347
interleukin-1 receptor-associated kinase 1 binding protein 1
IDBP-809351
interleukin-1 receptor-associated kinase 1 binding protein 1
IDBP-809353
interleukin-1 receptor-associated kinase 1 binding protein 1
IDBP-809355
interleukin-1 receptor-associated kinase 1 binding protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20534545
IRAK1BP1 down-regulates Toll-like receptor-mediated transcription of several pro-inflammatory cytokines by changing the transcriptional profile of activated cells, leading to an increase in IL-10 production and promoting LPS tolerance.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 6:78867472-78946440
Strand Forward strand
Band q14.1
Transcripts
ENST00000369940 ENSP00000358956
ENST00000606868 ENSP00000475570
ENST00000607739 ENSP00000475503
ENST00000606929 ENSP00000475395
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032251
View Gene Order
ENSBTAG00000020825
Not yet available
Pathways
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt Q5VVH5
TrEMBL U3KQ34 U3KQ57
UniProt Splice Variant
Entrez Gene 134728
UniGene
RefSeq NM_001010844 XM_005248654 XM_005248655
HUGO HGNC:17368
OMIM 615375
CCDS CCDS34488
HPRD
IMGT
EMBL AL356776 AL450327 BC112253 BC112255 CH471051
GenPept AAI12254 AAI12256 CAH70883 EAW48721
RNA Seq Atlas 134728

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca