Version 5.4
| Homo sapiens Gene: C1QB | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-93747.5 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | C1QB | ||||||||||||||||||
| Gene Name | complement component 1, q subcomponent, B chain | ||||||||||||||||||
| Synonyms | |||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000173369 | ||||||||||||||||||
| Encoded Proteins |
complement component 1, q subcomponent, B chain
complement component 1, q subcomponent, B chain
complement component 1, q subcomponent, B chain
complement component 1, q subcomponent, B chain
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| InnateDB Annotation | |||||||||||||||||||
| Summary |
C1QB is the B-chain of the C1Q, the recognition subunit of Complement component 1 (C1), is a multimolecular protease that triggers the classical pathway of complement and has a major role in the host defence against pathogens.
C1Q is involved in the modulation of various immune cells such as dendritic cells, platelets, microglia cells and lymphocytes. C1Q has roles in clearance of apoptotic cells as well as a range of cell processes such as differentiation, chemotaxis, aggregation and adhesion, and pathogenesis of neurodegenerative diseases.
C1QA :: C1QB :: C1QC (C1Q) is a versatile innate immune molecule that recognizes an array of self, non-self and altered-self ligands. The broad-spectrum of ligand specificity is facilitated by the modular organization of the heterotrimeric globular region and its ability to change its confirmation.
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| InnateDB Annotation from Orthologs | |||||||||||||||||||
| Summary |
[Mus musculus] C1qa :: C1qb :: C1qc (C1q) is a versatile innate immune molecule that recognizes an array of self, non-self and altered-self ligands. The broad-spectrum of ligand specificity is facilitated by the modular organization of the heterotrimeric globular region and its ability to change its confirmation.
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| Entrez Gene | |||||||||||||||||||
| Summary |
This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the B-chain polypeptide of human complement subcomponent C1q [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 1:22652762-22661538 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | p36.12 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Classical antibody-mediated complement activation pathway
Initial triggering of complement pathway
Innate Immune System pathway
Creation of C4 and C2 activators pathway
Immune System pathway
Complement cascade pathway
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| KEGG |
Complement and coagulation cascades pathway
Systemic lupus erythematosus pathway
Prion diseases pathway
Staphylococcus aureus infection pathway
Chagas disease (American trypanosomiasis) pathway
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| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | P02746 | ||||||||||||||||||
| TrEMBL | A0A024RAB9 D6R934 D6RGJ1 Q6LDZ7 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 713 | ||||||||||||||||||
| UniGene | |||||||||||||||||||
| RefSeq | NM_000491 XM_005245982 | ||||||||||||||||||
| HUGO | HGNC:1242 | ||||||||||||||||||
| OMIM | 120570 | ||||||||||||||||||
| CCDS | CCDS228 | ||||||||||||||||||
| HPRD | |||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AL158086 BC008983 CH471134 L80036 M36278 X03084 | ||||||||||||||||||
| GenPept | AAC41692 AAH08983 AAQ67338 CAA26880 CAI22896 EAW95019 EAW95020 EAW95021 | ||||||||||||||||||
| RNA Seq Atlas | 713 | ||||||||||||||||||