Homo sapiens Gene: E2F2
Summary
InnateDB Gene IDBG-93950.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol E2F2
Gene Name E2F transcription factor 2
Synonyms E2F-2;
Species Homo sapiens
Ensembl Gene ENSG00000007968
Encoded Proteins
E2F transcription factor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46%% amino acid identity to E2F1. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:23506430-23531220
Strand Reverse strand
Band p36.12
Transcripts
ENST00000361729 ENSP00000355249
ENST00000487237
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 42 [view]
Protein-Protein 27 [view]
Protein-DNA 15 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001047 core promoter binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
Biological Process
GO:0000278 mitotic cell cycle
GO:0006355 regulation of transcription, DNA-templated
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0051726 regulation of cell cycle
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
GO:1990086 lens fiber cell apoptotic process
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
DNA Replication pathway
G1 Phase pathway
Cellular responses to stress pathway
Oncogene Induced Senescence pathway
Mitotic G1-G1/S phases pathway
Cyclin D associated events in G1 pathway
DNA Replication Pre-Initiation pathway
Cell Cycle pathway
Association of licensing factors with the pre-replicative complex pathway
Cellular Senescence pathway
M/G1 Transition pathway
Cell Cycle, Mitotic pathway
CDC6 association with the ORC:origin complex pathway
Regulation of DNA replication pathway
Oxidative Stress Induced Senescence pathway
Assembly of the pre-replicative complex pathway
KEGG
Cell cycle pathway
Pathways in cancer pathway
Pancreatic cancer pathway
Glioma pathway
Prostate cancer pathway
Melanoma pathway
Bladder cancer pathway
Chronic myeloid leukemia pathway
Small cell lung cancer pathway
Non-small cell lung cancer pathway
INOH
PID BIOCARTA
PID NCI
E2F transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.194333 Hs.625101
RefSeq NM_004091 XM_005245748 XM_005245749
HUGO
OMIM
CCDS CCDS236
HPRD 02692
IMGT
EMBL
GenPept
RNA Seq Atlas