Version 5.4
Homo sapiens Gene: ID3
Summary
InnateDB Gene IDBG-93963.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ID3
Gene Name inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
Synonyms bHLHb25; HEIR-1
Species Homo sapiens
Ensembl Gene ENSG00000117318
Encoded Proteins
IDBP-93965
inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with other HLH proteins. However, the encoded protein lacks a basic DNA-binding domain and therefore inhibits the DNA binding of any HLH protein with which it interacts. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:23557918-23559794
Strand Reverse strand
Band p36.12
Transcripts
ENST00000374561 ENSP00000363689
ENST00000463312
ENST00000486541
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 42 [view]
Protein-Protein 38 [view]
Protein-DNA 3 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0019904 protein domain specific binding
GO:0046983 protein dimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001656 metanephros development
GO:0006275 regulation of DNA replication
GO:0006351 transcription, DNA-templated
GO:0007275 multicellular organismal development
GO:0007417 central nervous system development
GO:0007507 heart development
GO:0007517 muscle organ development
GO:0009611 response to wounding
GO:0030182 neuron differentiation
GO:0030855 epithelial cell differentiation
GO:0030903 notochord development
GO:0042476 odontogenesis
GO:0043065 positive regulation of apoptotic process
GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045662 negative regulation of myoblast differentiation
GO:0045668 negative regulation of osteoblast differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0015630 microtubule cytoskeleton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000007872
View Gene Order
ENSBTAG00000030425
Not yet available
Pathways
NETPATH
NetPath_5
ID pathway
REACTOME
KEGG
hsa04350
TGF-beta signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_002167
HUGO
OMIM
CCDS CCDS237
HPRD 02608
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca