Homo sapiens Gene: CNKSR1
Summary
InnateDB Gene IDBG-94499.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CNKSR1
Gene Name connector enhancer of kinase suppressor of Ras 1
Synonyms CNK; CNK1;
Species Homo sapiens
Ensembl Gene ENSG00000142675
Encoded Proteins
connector enhancer of kinase suppressor of Ras 1
connector enhancer of kinase suppressor of Ras 1
connector enhancer of kinase suppressor of Ras 1
connector enhancer of kinase suppressor of Ras 1
connector enhancer of kinase suppressor of Ras 1
connector enhancer of kinase suppressor of Ras 1
connector enhancer of kinase suppressor of Ras 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target. It is involved in regulation of RAF in the MAPK pathway and may also play a role in a MAPK-independent pathway. [provided by RefSeq, Jul 2008]
This gene encodes a protein containing several motifs involved in protein-protein interaction, including PDZ, PH (Pleckstrin homology), and SAM (sterile alpha motif) domains. The encoded protein acts as a scaffold component for receptor tyrosine kinase signaling and may mediate crosstalk between different signaling pathways. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:26177403-26189886
Strand Forward strand
Band p36.11
Transcripts
ENST00000361530 ENSP00000354609
ENST00000374253 ENSP00000363371
ENST00000480348
ENST00000465415
ENST00000482227 ENSP00000435880
ENST00000481077 ENSP00000432057
ENST00000480617
ENST00000484874
ENST00000525687 ENSP00000437038
ENST00000531191 ENSP00000431817
ENST00000524529
ENST00000531150
ENST00000528001
ENST00000528281 ENSP00000434047
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
Experimentally validated
Total 23 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016301 kinase activity
GO:0030674 protein binding, bridging
Biological Process
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007265 Ras protein signal transduction
GO:0007266 Rho protein signal transduction
GO:0016310 phosphorylation
Cellular Component
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005938 cell cortex
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
IL3-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.16232
RefSeq NM_001297647 NM_001297648 NM_006314 XM_006710279 XM_006710280 XM_006710281 XM_006710282
HUGO
OMIM
CCDS CCDS276 CCDS72732
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas