Version 5.4
Homo sapiens Gene: HACE1
Summary
InnateDB Gene IDBG-94750.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HACE1
Gene Name HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000085382
Encoded Proteins
IDBP-94754
HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1
IDBP-94756
HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1
IDBP-385658
HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1
IDBP-485469
HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1
IDBP-480302
HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1
IDBP-473759
HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1
IDBP-476565
HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1
IDBP-476669
HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1
IDBP-481252
HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 27213432
HACE1 plays an inhibitory role in virus-induced signalling by disrupting the MAVS-TRAF3 complex.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 6:104728093-104859919
Strand Reverse strand
Band q16.3
Transcripts
ENST00000369127
ENST00000262903 ENSP00000262903
ENST00000369125 ENSP00000358121
ENST00000416605 ENSP00000392425
ENST00000517995
ENST00000518503 ENSP00000429520
ENST00000518402 ENSP00000428110
ENST00000518228
ENST00000517424 ENSP00000430898
ENST00000519645 ENSP00000429765
ENST00000524020 ENSP00000427901
ENST00000521962 ENSP00000430669
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.
Experimentally validated
Total 56 [view]
Protein-Protein 56 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0016874 ligase activity
GO:0017137 Rab GTPase binding
GO:0048365 Rac GTPase binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007030 Golgi organization
GO:0007049 cell cycle
GO:0016567 protein ubiquitination
GO:0016601 Rac protein signal transduction
GO:0030334 regulation of cell migration
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0045087 innate immune response (InnateDB)
GO:0061025 membrane fusion
GO:0070936 protein K48-linked ubiquitination
Cellular Component
GO:0000139 Golgi membrane
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0032580 Golgi cisterna membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038822
View Gene Order
ENSBTAG00000001533
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.434340 Hs.604251 Hs.609954
RefSeq NM_020771 XM_005267073 XM_006715528
HUGO
OMIM
CCDS CCDS5050
HPRD 17086
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca