InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FGR

Summary

InnateDB Gene

IDBG-94937.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FGR

Gene Name

Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog

Synonyms

c-fgr; c-src2; p55-Fgr; p55c-fgr; p58-Fgr; p58c-fgr; SRC2

Species

Homo sapiens

Ensembl Gene

ENSG00000000938

Encoded Proteins

IDBP-94939

Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog

IDBP-94941

Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog

IDBP-94943

Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog

IDBP-231251

Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog

IDBP-377057

Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:27612064-27635277

Strand

Reverse strand

Band

p35.3

Transcripts

ENST00000374005	ENSP00000363117
ENST00000374004	ENSP00000363116
ENST00000374003	ENSP00000363115
ENST00000399173	ENSP00000382126
ENST00000457296	ENSP00000407670
ENST00000475472
ENST00000468038

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	31 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001784	phosphotyrosine binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019901	protein kinase binding
GO:0034987	immunoglobulin receptor binding
GO:0034988	Fc-gamma receptor I complex binding

Biological Process

GO:0002768	immune response-regulating cell surface receptor signaling pathway
GO:0006468	protein phosphorylation
GO:0007229	integrin-mediated signaling pathway
GO:0007596	blood coagulation
GO:0008360	regulation of cell shape
GO:0009615	response to virus
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030335	positive regulation of cell migration
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043306	positive regulation of mast cell degranulation
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity
GO:0045087	innate immune response
GO:0045088	regulation of innate immune response
GO:0045859	regulation of protein kinase activity
GO:0046777	protein autophosphorylation
GO:0050715	positive regulation of cytokine secretion
GO:0050764	regulation of phagocytosis
GO:0050830	defense response to Gram-positive bacterium

Cellular Component

GO:0005743	mitochondrial inner membrane
GO:0005758	mitochondrial intermembrane space
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0015629	actin cytoskeleton
GO:0032587	ruffle membrane
GO:0070062	extracellular vesicular exosome