Version 5.4
Homo sapiens Gene: SEC63
Summary
InnateDB Gene IDBG-94972.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SEC63
Gene Name SEC63 homolog (S. cerevisiae)
Synonyms DNAJC23; ERdj2; PRO2507; SEC63L
Species Homo sapiens
Ensembl Gene ENSG00000025796
Encoded Proteins
IDBP-94974
SEC63 homolog (S. cerevisiae)
IDBP-385781
SEC63 homolog (S. cerevisiae)
IDBP-385784
SEC63 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:107867756-107958189
Strand Reverse strand
Band q21
Transcripts
ENST00000369002 ENSP00000357998
ENST00000429168 ENSP00000403144
ENST00000446496 ENSP00000410968
ENST00000459782
ENST00000473746
ENST00000465210
ENST00000466419
ENST00000489455
ENST00000484803
ENST00000460009
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0005488 binding
GO:0005515 protein binding
GO:0008565 protein transporter activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0001889 liver development
GO:0006612 protein targeting to membrane
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0006620 posttranslational protein targeting to membrane
GO:0006807 nitrogen compound metabolic process
GO:0010259 multicellular organismal aging
GO:0031204 posttranslational protein targeting to membrane, translocation
GO:0072001 renal system development
Cellular Component
GO:0005622 intracellular
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000019802
View Gene Order
ENSBTAG00000016562
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa03060
Protein export pathway
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.26904 Hs.603080 Hs.716394
RefSeq NM_007214
HUGO
OMIM
CCDS CCDS5061
HPRD 09783
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca