InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SNX3

Summary

InnateDB Gene

IDBG-94996.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SNX3

Gene Name

sorting nexin 3

Synonyms

Grd19; MCOPS8; SDP3

Species

Homo sapiens

Ensembl Gene

ENSG00000112335

Encoded Proteins

IDBP-95000

sorting nexin 3

IDBP-95002

sorting nexin 3

IDBP-95004

sorting nexin 3

IDBP-385807

sorting nexin 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like most family members. This protein interacts with phosphatidylinositol-3-phosphate, and is involved in protein trafficking. [provided by RefSeq, Jul 2008]
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like most family members. This protein interacts with phosphatidylinositol-3-phosphate, and is involved in protein trafficking. A pseudogene of this gene is present on the sex chromosomes. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:108211222-108261260

Strand

Reverse strand

Band

q21

Transcripts

ENST00000349379	ENSP00000296991
ENST00000230085	ENSP00000230085
ENST00000368979	ENSP00000357975
ENST00000426155	ENSP00000401779

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.

Experimentally validated
Total	38 [view]
Protein-Protein	32 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019903	protein phosphatase binding
GO:0032266	phosphatidylinositol-3-phosphate binding
GO:0035091	phosphatidylinositol binding

Biological Process

GO:0006886	intracellular protein transport
GO:0006897	endocytosis
GO:0032268	regulation of cellular protein metabolic process
GO:0033157	regulation of intracellular protein transport
GO:0033572	transferrin transport
GO:0042541	hemoglobin biosynthetic process

Cellular Component

GO:0005737	cytoplasm
GO:0005769	early endosome
GO:0005829	cytosol
GO:0010008	endosome membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000019804

View Gene Order

ENSBTAG00000018801

Not yet available

Pathways

NETPATH

REACTOME

REACT_228331

Signaling by WNT in cancer pathway

REACT_11045

Signaling by Wnt pathway

REACT_228014

WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 pathway

REACT_111102

Signal Transduction pathway

REACT_163710

WNT ligand biogenesis and trafficking pathway

REACT_116125

Disease pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.12102

RefSeq

NM_001300929 NM_003795 NM_152827 XM_005267192

HUGO

OMIM

CCDS

CCDS5064 CCDS5065 CCDS75501

HPRD

09333

IMGT

EMBL

GenPept

RNA Seq Atlas