Version 5.4
Homo sapiens Gene: SLC22A16
Summary
InnateDB Gene IDBG-95255.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC22A16
Gene Name solute carrier family 22 (organic cation/carnitine transporter), member 16
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000004809
Encoded Proteins
IDBP-95257
solute carrier family 22 (organic cation/carnitine transporter), member 16
IDBP-95259
solute carrier family 22 (organic cation/carnitine transporter), member 16
IDBP-386038
solute carrier family 22 (organic cation/carnitine transporter), member 16
IDBP-386042
solute carrier family 22 (organic cation/carnitine transporter), member 16
IDBP-386043
solute carrier family 22 (organic cation/carnitine transporter), member 16
IDBP-386044
solute carrier family 22 (organic cation/carnitine transporter), member 16
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the organic zwitterion transporter protein family which transports carnitine. The encoded protein has also been shown to transport anticancer drugs like bleomycin (PMID: 20037140) successful treatment has been correlated with the level of activity of this transporter in tumor cells. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:110424687-110476641
Strand Reverse strand
Band q21
Transcripts
ENST00000368919 ENSP00000357915
ENST00000330550 ENSP00000328583
ENST00000451557 ENSP00000395642
ENST00000434949 ENSP00000409306
ENST00000437378 ENSP00000416310
ENST00000424139 ENSP00000401007
ENST00000460159
ENST00000461487
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005275 amine transmembrane transporter activity
GO:0015101 organic cation transmembrane transporter activity
GO:0015226 carnitine transmembrane transporter activity
GO:0022857 transmembrane transporter activity
Biological Process
GO:0007275 multicellular organismal development
GO:0007283 spermatogenesis
GO:0007338 single fertilization
GO:0015695 organic cation transport
GO:0015837 amine transport
GO:0015879 carnitine transport
GO:0030154 cell differentiation
GO:0030317 sperm motility
GO:0046717 acid secretion
GO:0055085 transmembrane transport
GO:1902603 carnitine transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000019834
View Gene Order
ENSBTAG00000010507
Not yet available
Pathways
NETPATH
REACTOME
REACT_22357
Organic cation transport pathway
REACT_19305
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_22345
Organic cation/anion/zwitterion transport pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.520319
RefSeq NM_033125
HUGO
OMIM
CCDS CCDS5084
HPRD 12202
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca