Homo sapiens Gene: PEF1
Summary
InnateDB Gene IDBG-95478.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PEF1
Gene Name penta-EF-hand domain containing 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000162517
Encoded Proteins
penta-EF-hand domain containing 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. The encoded protein has been shown to form a heterodimer with the programmed cell death 6 gene product and may modulate its function in Ca(2+) signaling. Alternative splicing results in multiple transcript variants and a pseudogene has been identified on chromosome 1.[provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:31629862-31644896
Strand Reverse strand
Band p35.2
Transcripts
ENST00000373703 ENSP00000362807
ENST00000461006
ENST00000478502
ENST00000489164
ENST00000492061
ENST00000496805
ENST00000472443
ENST00000471219
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 13 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004198 calcium-dependent cysteine-type endopeptidase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
Biological Process
GO:0006508 proteolysis
GO:0051592 response to calcium ion
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.470417
RefSeq NM_012392
HUGO
OMIM
CCDS CCDS345
HPRD 10143
IMGT
EMBL
GenPept
RNA Seq Atlas