Homo sapiens Gene: LAMA4
InnateDB Gene IDBG-95551.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LAMA4
Gene Name laminin, alpha 4
Synonyms CMD1JJ; LAMA3; LAMA4*-1
Species Homo sapiens
Ensembl Gene ENSG00000112769
Encoded Proteins
laminin, alpha 4
laminin, alpha 4
laminin, alpha 4
laminin, alpha 4
laminin, alpha 4
laminin, alpha 4
laminin, alpha 4
laminin, alpha 4
laminin, alpha 4
laminin, alpha 4
laminin, alpha 4
laminin, alpha 4
laminin, alpha 4
laminin, alpha 4
laminin, alpha 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the alpha chain isoform laminin, alpha 4. The domain structure of alpha 4 is similar to that of alpha 3, both of which resemble truncated versions of alpha 1 and alpha 2, in that approximately 1,200 residues at the N-terminus (domains IV, V and VI) have been lost. Laminin, alpha 4 contains the C-terminal G domain which distinguishes all alpha chains from the beta and gamma chains. The RNA analysis from adult and fetal tissues revealed developmental regulation of expression, however, the exact function of laminin, alpha 4 is not known. Tissue-specific utilization of alternative polyA-signal has been described in literature. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:112108760-112254939
Strand Reverse strand
Band q21
ENST00000230538 ENSP00000230538
ENST00000389463 ENSP00000374114
ENST00000368640 ENSP00000357629
ENST00000243219 ENSP00000243219
ENST00000368638 ENSP00000357627
ENST00000424408 ENSP00000416470
ENST00000431543 ENSP00000412136
ENST00000453937 ENSP00000398226
ENST00000455073 ENSP00000408604
ENST00000522006 ENSP00000429488
ENST00000523765 ENSP00000427837
ENST00000521732 ENSP00000427865
ENST00000521398 ENSP00000430336
ENST00000519932 ENSP00000428583
ENST00000521690 ENSP00000430415
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated
Total 20 [view]
Protein-Protein 17 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004713 protein tyrosine kinase activity
GO:0004871 signal transducer activity
GO:0005102 receptor binding
GO:0005201 extracellular matrix structural constituent
GO:0005515 protein binding
Biological Process
GO:0001568 blood vessel development
GO:0006468 protein phosphorylation
GO:0007155 cell adhesion
GO:0007172 signal complex assembly
GO:0030155 regulation of cell adhesion
GO:0030198 extracellular matrix organization
GO:0030334 regulation of cell migration
GO:0045995 regulation of embryonic development
GO:0050873 brown fat cell differentiation
Cellular Component
GO:0005576 extracellular region
GO:0005604 basement membrane
GO:0005605 basal lamina
GO:0005606 laminin-1 complex
GO:0005925 focal adhesion
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Extracellular matrix organization pathway
ECM proteoglycans pathway
Non-integrin membrane-ECM interactions pathway
Laminin interactions pathway
ECM-receptor interaction pathway
Small cell lung cancer pathway
Focal adhesion pathway
Pathways in cancer pathway
Amoebiasis pathway
African trypanosomiasis pathway
Toxoplasmosis pathway
Beta1 integrin cell surface interactions
Beta3 integrin cell surface interactions
FOXM1 transcription factor network
SwissProt Q16363
UniProt Splice Variant
Entrez Gene 3910
UniGene Hs.654572
RefSeq NM_001105206 XM_005266983 XM_005266984 XM_006715480 NM_001105207 NM_001105208 NM_001105209 NM_002290 XM_006715481
OMIM 600133
CCDS CCDS43491 CCDS34514 CCDS43492
HPRD 02532
EMBL AB210027 AL590106 BC004241 BT006690 S78569 X70904 X76939 X91171 Y14240 Z99289
GenPept AAB34635 AAH04241 AAP35336 BAE06109 CAA50261 CAA54258 CAA62596 CAA74636 CAI12948 CAI12949 CAI12950 CAI42325
RNA Seq Atlas 3910