Version 5.4
Homo sapiens Gene: KLHL7
Summary
InnateDB Gene IDBG-9558.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KLHL7
Gene Name kelch-like 7 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000122550
Encoded Proteins
IDBP-9562
kelch-like 7 (Drosophila)
IDBP-9564
kelch-like 7 (Drosophila)
IDBP-294892
kelch-like 7 (Drosophila)
IDBP-294890
kelch-like 7 (Drosophila)
IDBP-367973
kelch-like 7 (Drosophila)
IDBP-473651
kelch-like 7 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a BTB-Kelch-related protein. The encoded protein may be involved in protein degradation. Mutations in this gene have been associated with retinitis pigmentosa 42. [provided by RefSeq, Feb 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:23105758-23177914
Strand Forward strand
Band p15.3
Transcripts
ENST00000339077 ENSP00000343273
ENST00000322275 ENSP00000323270
ENST00000410047 ENSP00000386999
ENST00000409689 ENSP00000386263
ENST00000414163 ENSP00000404181
ENST00000479288
ENST00000521082 ENSP00000430351
ENST00000459661
ENST00000491352
ENST00000479700
ENST00000477076
ENST00000469576
ENST00000469845
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0016567 protein ubiquitination
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0031463 Cul3-RING ubiquitin ligase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028986
View Gene Order
ENSBTAG00000016010
Not yet available
Cross-References
SwissProt
TrEMBL H7C259
UniProt Splice Variant
Entrez Gene 55975
UniGene Hs.654817 Hs.708589
RefSeq NM_001031710 NM_001172428 NM_018846
HUGO HGNC:15646
OMIM 611119
CCDS CCDS34609 CCDS5378 CCDS55095
HPRD 13927
IMGT
EMBL AC005082 AC006039 AC073992
GenPept
RNA Seq Atlas 55975

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca