Version 5.4
Homo sapiens Gene: FRK
Summary
InnateDB Gene IDBG-95607.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FRK
Gene Name fyn-related kinase
Synonyms GTK; PTK5; RAK
Species Homo sapiens
Ensembl Gene ENSG00000111816
Encoded Proteins
IDBP-807256
fyn-related Src family tyrosine kinase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:115931149-116060758
Strand Reverse strand
Band q22.1
Transcripts
ENST00000606080 ENSP00000476145
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 14 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0008285 negative regulation of cell proliferation
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030154 cell differentiation
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000019779
View Gene Order
ENSBTAG00000020018
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt P42685
TrEMBL
UniProt Splice Variant
Entrez Gene 2444
UniGene
RefSeq NM_002031 XM_005266880 XM_005266881 XM_005266882
HUGO HGNC:3955
OMIM 606573
CCDS CCDS5103
HPRD
IMGT
EMBL AL121963 AL357141 BC012916 CH471051 U00803 U22322
GenPept AAA18284 AAC50116 AAH12916 CAB87592 CAI16469 EAW48241
RNA Seq Atlas 2444

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca