Homo sapiens Gene: NAGA
Summary
InnateDB Gene IDBG-9617.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NAGA
Gene Name N-acetylgalactosaminidase, alpha-
Synonyms D22S674; GALB;
Species Homo sapiens
Ensembl Gene ENSG00000198951
Encoded Proteins
N-acetylgalactosaminidase, alpha-
N-acetylgalactosaminidase, alpha-
N-acetylgalactosaminidase, alpha-
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary NAGA encodes the lysosomal enzyme alpha-N-acetylgalactosaminidase, which cleaves alpha-N-acetylgalactosaminyl moieties from glycoconjugates. Mutations in NAGA have been identified as the cause of Schindler disease types I and II (type II also known as Kanzaki disease). [provided by RefSeq, Jul 2008]
NAGA encodes the lysosomal enzyme alpha-N-acetylgalactosaminidase, which cleaves alpha-N-acetylgalactosaminyl moieties from glycoconjugates. Mutations in NAGA have been identified as the cause of Schindler disease types I and II (type II also known as Kanzaki disease). [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:42058354-42070842
Strand Reverse strand
Band q13.2
Transcripts
ENST00000396398 ENSP00000379680
ENST00000403363 ENSP00000385283
ENST00000402937 ENSP00000384603
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 3 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004557 alpha-galactosidase activity
GO:0008456 alpha-N-acetylgalactosaminidase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0009311 oligosaccharide metabolic process
GO:0016052 carbohydrate catabolic process
GO:0016139 glycoside catabolic process
GO:0019377 glycolipid catabolic process
GO:0046477 glycosylceramide catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Glycosphingolipid biosynthesis pathway
Lysosome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P17050
TrEMBL A0A024R1Q5
UniProt Splice Variant
Entrez Gene 4668
UniGene Hs.75372
RefSeq NM_000262 XM_005261615 XM_005261616 XM_005261617
HUGO HGNC:7631
OMIM 104170
CCDS CCDS14030
HPRD 00076
IMGT
EMBL BC000095 CH471095 CR456527 M29276 M38083 M59199 M62783 Z99716
GenPept AAA36351 AAA51677 AAA59902 AAB06718 AAH00095 CAB41237 CAG30413 EAW60484 EAW60485 EAW60486
RNA Seq Atlas 4668