Homo sapiens Gene: EIF2C4
Summary
InnateDB Gene IDBG-96231.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF2C4
Gene Name eukaryotic translation initiation factor 2C, 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000134698
Encoded Proteins
eukaryotic translation initiation factor 2C, 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic containing PAZ and PIWI domains, and it may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a cluster of closely related family members including argonaute 3, and eukaryotic translation initiation factor 2C, 1. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:35808172-35857890
Strand Forward strand
Band p34.3
Transcripts
ENST00000373210 ENSP00000362306
ENST00000488778
ENST00000496257
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 72 experimentally validated interaction(s) in this database.
Experimentally validated
Total 72 [view]
Protein-Protein 70 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0035198 miRNA binding
Biological Process
GO:0006402 mRNA catabolic process
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007219 Notch signaling pathway
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0010467 gene expression
GO:0035278 negative regulation of translation involved in gene silencing by miRNA
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0045087 innate immune response
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
Cellular Component
GO:0000932 cytoplasmic mRNA processing body
GO:0005829 cytosol
GO:0016020 membrane
GO:0016442 RISC complex
GO:0035068 micro-ribonucleoprotein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Signaling by FGFR in disease pathway
Cellular responses to stress pathway
Oncogene Induced Senescence pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
PI3K/AKT activation pathway
Downstream signaling of activated FGFR pathway
Ca2+ pathway pathway
Pre-NOTCH Expression and Processing pathway
MicroRNA (miRNA) biogenesis pathway
beta-catenin independent WNT signaling pathway
PI-3K cascade pathway
PI3K events in ERBB2 signaling pathway
DAP12 signaling pathway
Signaling by Wnt pathway
Small interfering RNA (siRNA) biogenesis pathway
Signaling by EGFR pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Innate Immune System pathway
Signaling by ERBB4 pathway
Signaling by SCF-KIT pathway
Post-transcriptional silencing by small RNAs pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
Pre-NOTCH Transcription and Translation pathway
Adaptive Immune System pathway
Immune System pathway
Downstream signal transduction pathway
Cellular Senescence pathway
NGF signalling via TRKA from the plasma membrane pathway
Signaling by NOTCH pathway
PI3K/AKT Signaling in Cancer pathway
Signaling by FGFR pathway
PIP3 activates AKT signaling pathway
Signaling by PDGF pathway
Signaling by ERBB2 pathway
Signaling by the B Cell Receptor (BCR) pathway
GAB1 signalosome pathway
Oxidative Stress Induced Senescence pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Gene Expression pathway
Disease pathway
PI3K events in ERBB4 signaling pathway
DAP12 interactions pathway
Regulatory RNA pathways pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9HCK5
TrEMBL Q9NXV9
UniProt Splice Variant
Entrez Gene 192670
UniGene Hs.471492 Hs.600138 Hs.615552 Hs.743238
RefSeq NM_017629 XM_005270578 XM_005270579
HUGO HGNC:18424
OMIM 607356
CCDS CCDS397
HPRD
IMGT
EMBL AB046787 AK000040 AL354864 AL359186 BC152450 CH471059
GenPept AAI52451 BAA90899 BAB13393 CAH71584 CAH73806 EAX07400
RNA Seq Atlas 192670