Version 5.4
Homo sapiens Gene: EIF2C4
Summary
InnateDB Gene IDBG-96231.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF2C4
Gene Name eukaryotic translation initiation factor 2C, 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000134698
Encoded Proteins
IDBP-96233
eukaryotic translation initiation factor 2C, 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic containing PAZ and PIWI domains, and it may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a cluster of closely related family members including argonaute 3, and eukaryotic translation initiation factor 2C, 1. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:35808172-35857890
Strand Forward strand
Band p34.3
Transcripts
ENST00000373210 ENSP00000362306
ENST00000488778
ENST00000496257
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 72 experimentally validated interaction(s) in this database.
Experimentally validated
Total 72 [view]
Protein-Protein 70 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0035198 miRNA binding
Biological Process
GO:0006402 mRNA catabolic process
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007219 Notch signaling pathway
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0010467 gene expression
GO:0035278 negative regulation of translation involved in gene silencing by miRNA
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0045087 innate immune response
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
Cellular Component
GO:0000932 cytoplasmic mRNA processing body
GO:0005829 cytosol
GO:0016020 membrane
GO:0016442 RISC complex
GO:0035068 micro-ribonucleoprotein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000042500
View Gene Order
ENSBTAG00000015220
Not yet available
Pathways
NETPATH
REACTOME
REACT_75829
PIP3 activates AKT signaling pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_12464
PI3K/AKT activation pathway
REACT_12578
GAB1 signalosome pathway
REACT_9417
Signaling by EGFR pathway
REACT_115961
PI3K events in ERBB4 signaling pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_116008
PI3K events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_118568
Pre-NOTCH Transcription and Translation pathway
REACT_21270
PI-3K cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_12417
MicroRNA (miRNA) biogenesis pathway
REACT_118699
Post-transcriptional silencing by small RNAs pathway
REACT_118560
Small interfering RNA (siRNA) biogenesis pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_120956
Cellular responses to stress pathway
REACT_169325
Oncogene Induced Senescence pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_172761
Ca2+ pathway pathway
REACT_118744
Pre-NOTCH Expression and Processing pathway
REACT_172694
beta-catenin independent WNT signaling pathway
REACT_11045
Signaling by Wnt pathway
REACT_163769
Role of LAT2/NTAL/LAB on calcium mobilization pathway
REACT_6802
Innate Immune System pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_111102
Signal Transduction pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_169274
Cellular Senescence pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_299
Signaling by NOTCH pathway
REACT_147723
PI3K/AKT Signaling in Cancer pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_169436
Oxidative Stress Induced Senescence pathway
REACT_118638
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
REACT_12472
Regulatory RNA pathways pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.471492 Hs.600138 Hs.615552 Hs.743238
RefSeq NM_017629 XM_005270578 XM_005270579
HUGO
OMIM
CCDS CCDS397
HPRD 09559
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca