Version 5.4
Homo sapiens Gene: SGK1
Summary
InnateDB Gene IDBG-96775.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SGK1
Gene Name serum/glucocorticoid regulated kinase 1
Synonyms SGK
Species Homo sapiens
Ensembl Gene ENSG00000118515
Encoded Proteins
IDBP-96777
serum/glucocorticoid regulated kinase 1
IDBP-96779
serum/glucocorticoid regulated kinase 1
IDBP-96783
serum/glucocorticoid regulated kinase 1
IDBP-387327
serum/glucocorticoid regulated kinase 1
IDBP-583771
serum/glucocorticoid regulated kinase 1
IDBP-587346
serum/glucocorticoid regulated kinase 1
IDBP-603724
serum/glucocorticoid regulated kinase 1
IDBP-590501
serum/glucocorticoid regulated kinase 1
IDBP-598082
serum/glucocorticoid regulated kinase 1
IDBP-597297
serum/glucocorticoid regulated kinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:134169246-134318112
Strand Reverse strand
Band q23.2
Transcripts
ENST00000367858 ENSP00000356832
ENST00000367857 ENSP00000356831
ENST00000367855
ENST00000237305 ENSP00000237305
ENST00000413996 ENSP00000396242
ENST00000477460
ENST00000474427
ENST00000475719 ENSP00000434302
ENST00000473704
ENST00000489458
ENST00000475882
ENST00000490149
ENST00000472859
ENST00000484353
ENST00000485771
ENST00000460769 ENSP00000431705
ENST00000461976 ENSP00000435577
ENST00000528577 ENSP00000434450
ENST00000531782
ENST00000525877
ENST00000524764
ENST00000534658
ENST00000524387
ENST00000531575
ENST00000532021
ENST00000532856
ENST00000530421
ENST00000525700
ENST00000524929 ENSP00000435724
ENST00000533224 ENSP00000436470
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 78 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 78 [view]
Protein-Protein 75 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005246 calcium channel regulator activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0015459 potassium channel regulator activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0017080 sodium channel regulator activity
GO:0017081 chloride channel regulator activity
GO:0035091 phosphatidylinositol binding
Biological Process
GO:0001558 regulation of cell growth
GO:0006468 protein phosphorylation
GO:0006814 sodium ion transport
GO:0006915 apoptotic process
GO:0006950 response to stress
GO:0006974 cellular response to DNA damage stimulus
GO:0007616 long-term memory
GO:0008217 regulation of blood pressure
GO:0030334 regulation of cell migration
GO:0032411 positive regulation of transporter activity
GO:0034220 ion transmembrane transport
GO:0042127 regulation of cell proliferation
GO:0042981 regulation of apoptotic process
GO:0050790 regulation of catalytic activity
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
GO:0055085 transmembrane transport
GO:0060453 regulation of gastric acid secretion
GO:0070294 renal sodium ion absorption
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000019970
View Gene Order
ENSBTAG00000004269
Not yet available
Pathways
NETPATH
NetPath_14
IL2 pathway
NetPath_18
IL6 pathway
NetPath_25
FSH pathway
REACTOME
REACT_160189
Stimuli-sensing channels pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_25300
Ion channel transport pathway
KEGG
hsa04960
Aldosterone-regulated sodium reabsorption pathway
INOH
PID NCI
pi3kcipathway
Class I PI3K signaling events
mtor_4pathway
mTOR signaling pathway
foxopathway
FoxO family signaling
reg_gr_pathway
Glucocorticoid receptor regulatory network
insulin_pathway
Insulin Pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.510078 Hs.592724 Hs.615835 Hs.736222
RefSeq NM_001143676 NM_001143677 NM_001143678 NM_005627
HUGO
OMIM
CCDS CCDS47476 CCDS47477 CCDS47478 CCDS5170
HPRD 04264
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca