Version 5.4
Homo sapiens Gene: PTPRF
Summary
InnateDB Gene IDBG-97490.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTPRF
Gene Name protein tyrosine phosphatase, receptor type, F
Synonyms BNAH2; LAR
Species Homo sapiens
Ensembl Gene ENSG00000142949
Encoded Proteins
IDBP-97494
protein tyrosine phosphatase, receptor type, F
IDBP-97502
protein tyrosine phosphatase, receptor type, F
IDBP-382207
protein tyrosine phosphatase, receptor type, F
IDBP-382216
protein tyrosine phosphatase, receptor type, F
IDBP-382217
protein tyrosine phosphatase, receptor type, F
IDBP-382219
protein tyrosine phosphatase, receptor type, F
IDBP-382221
protein tyrosine phosphatase, receptor type, F
IDBP-809822
protein tyrosine phosphatase, receptor type, F
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:43525187-43623666
Strand Forward strand
Band p34.2
Transcripts
ENST00000359947 ENSP00000353030
ENST00000372407 ENSP00000361484
ENST00000372405
ENST00000438120 ENSP00000398822
ENST00000436724
ENST00000437607 ENSP00000413306
ENST00000412568 ENSP00000391764
ENST00000429895 ENSP00000408952
ENST00000414879 ENSP00000416343
ENST00000496043
ENST00000481019
ENST00000467464
ENST00000496447
ENST00000463041
ENST00000477970
ENST00000617451 ENSP00000483557
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 29 [view]
Protein-Protein 27 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0008201 heparin binding
GO:0016791 phosphatase activity
GO:0032403 protein complex binding
Biological Process
GO:0006470 protein dephosphorylation
GO:0007155 cell adhesion
GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway
GO:0016311 dephosphorylation
GO:0016477 cell migration
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:1900121 negative regulation of receptor binding
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000033295
View Gene Order
ENSBTAG00000000253
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa04520
Adherens junction pathway
hsa04910
Insulin signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F2Z3B8
UniProt Splice Variant
Entrez Gene 5792
UniGene Hs.272062
RefSeq XM_005271081 XM_006710796 XM_006710800 NM_002840 NM_130440 XM_005271079 XM_005271080 XM_006710795 XM_006710797 XM_006710798 XM_006710799 XM_006710801
HUGO HGNC:9670
OMIM 179590
CCDS CCDS489 CCDS490
HPRD 01552
IMGT
EMBL AC092815 AL583862
GenPept
RNA Seq Atlas 5792

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca