Homo sapiens Gene: ST3GAL3
Summary
InnateDB Gene IDBG-97520.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ST3GAL3
Gene Name ST3 beta-galactoside alpha-2,3-sialyltransferase 3
Synonyms EIEE15; MRT12; SIAT6; ST3GALII; ST3GalIII; ST3N;
Species Homo sapiens
Ensembl Gene ENSG00000126091
Encoded Proteins
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi apparatus but can be proteolytically processed to a soluble form. This protein is a member of glycosyltransferase family 29. Mutations in this gene have been associated with autosomal recessive nonsymdromic mental retardation-12 (MRT12). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:43705824-43931165
Strand Forward strand
Band p34.1
Transcripts
ENST00000361392 ENSP00000355341
ENST00000361400 ENSP00000354748
ENST00000262915 ENSP00000262915
ENST00000347631 ENSP00000317192
ENST00000330208 ENSP00000333494
ENST00000361746 ENSP00000354657
ENST00000351035 ENSP00000316999
ENST00000372374 ENSP00000361449
ENST00000372372 ENSP00000361447
ENST00000335430 ENSP00000335633
ENST00000353126 ENSP00000330463
ENST00000361812 ENSP00000355201
ENST00000372368 ENSP00000361443
ENST00000332628 ENSP00000329755
ENST00000372369 ENSP00000361444
ENST00000372365 ENSP00000361440
ENST00000372366 ENSP00000361441
ENST00000372367 ENSP00000361442
ENST00000372362 ENSP00000361437
ENST00000489897 ENSP00000437206
ENST00000479383 ENSP00000432214
ENST00000484868
ENST00000490541 ENSP00000435018
ENST00000469715 ENSP00000431700
ENST00000461066 ENSP00000433668
ENST00000461375
ENST00000490502 ENSP00000436298
ENST00000495482
ENST00000532911 ENSP00000431816
ENST00000530154 ENSP00000434686
ENST00000531451 ENSP00000435603
ENST00000528371 ENSP00000434876
ENST00000531993 ENSP00000432682
ENST00000533933 ENSP00000432965
ENST00000533212 ENSP00000435621
ENST00000533997 ENSP00000432071
ENST00000530581 ENSP00000437293
ENST00000531816 ENSP00000434378
ENST00000545417 ENSP00000439634
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity
GO:0008118 N-acetyllactosaminide alpha-2,3-sialyltransferase activity
GO:0008373 sialyltransferase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006486 protein glycosylation
GO:0016266 O-glycan processing
GO:0018146 keratan sulfate biosynthetic process
GO:0030203 glycosaminoglycan metabolic process
GO:0042339 keratan sulfate metabolic process
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0044281 small molecule metabolic process
GO:0097503 sialylation
Cellular Component
GO:0000139 Golgi membrane
GO:0005576 extracellular region
GO:0030173 integral component of Golgi membrane
GO:0032580 Golgi cisterna membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Mucopolysaccharidoses pathway
Post-translational protein modification pathway
Pre-NOTCH Expression and Processing pathway
Myoclonic epilepsy of Lafora pathway
Defective B4GALT7 causes EDS, progeroid type pathway
Defective CHST6 causes MCDC1 pathway
Keratan sulfate/keratin metabolism pathway
MPS VI - Maroteaux-Lamy syndrome pathway
Defective PAPSS2 causes SEMD-PA pathway
Metabolism of carbohydrates pathway
Keratan sulfate biosynthesis pathway
MPS IIID - Sanfilippo syndrome D pathway
Synthesis of substrates in N-glycan biosythesis pathway
Defective SLC26A2 causes chondrodysplasias pathway
O-linked glycosylation of mucins pathway
Asparagine N-linked glycosylation pathway
Signal Transduction pathway
O-linked glycosylation pathway
Sialic acid metabolism pathway
MPS IX - Natowicz syndrome pathway
Defective EXT1 causes exostoses 1, TRPS2 and CHDS pathway
Metabolism of proteins pathway
Defective CHST14 causes EDS, musculocontractural type pathway
MPS IV - Morquio syndrome B pathway
Defective B3GAT3 causes JDSSDHD pathway
Defective CHST3 causes SEDCJD pathway
MPS IV - Morquio syndrome A pathway
Defective EXT2 causes exostoses 2 pathway
Diseases associated with glycosaminoglycan metabolism pathway
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
MPS II - Hunter syndrome pathway
Signaling by NOTCH pathway
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) pathway
Glycosaminoglycan metabolism pathway
Diseases of glycosylation pathway
Pre-NOTCH Processing in Golgi pathway
MPS VII - Sly syndrome pathway
Termination of O-glycan biosynthesis pathway
Defective CHSY1 causes TPBS pathway
Metabolism pathway
MPS I - Hurler syndrome pathway
MPS IIIA - Sanfilippo syndrome A pathway
MPS IIIC - Sanfilippo syndrome C pathway
Disease pathway
Glycogen storage diseases pathway
MPS IIIB - Sanfilippo syndrome B pathway
KEGG
Other types of O-glycan biosynthesis pathway
Glycosaminoglycan biosynthesis pathway
Glycosphingolipid biosynthesis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q11203
TrEMBL
UniProt Splice Variant
Entrez Gene 6487
UniGene Hs.576181 Hs.597915
RefSeq NM_174970 NM_001270459 NM_001270460 NM_001270461 NM_001270462 NM_001270463 NM_001270464 NM_001270465 NM_001270466 NM_006279 NM_174963 NM_174964 NM_174965 NM_174966 NM_174967 NM_174968 NM_174969 NM_174971
HUGO HGNC:10866
OMIM 606494
CCDS CCDS53310 CCDS492 CCDS493 CCDS494 CCDS495 CCDS496 CCDS497 CCDS498 CCDS499 CCDS500 CCDS57988 CCDS57989 CCDS57990 CCDS57991 CCDS57992 CCDS57993 CCDS57994
HPRD 05930
IMGT
EMBL AF425851 AF425852 AF425853 AF425854 AF425855 AF425856 AF425857 AF425858 AF425859 AF425860 AF425861 AF425862 AF425863 AF425864 AF425865 AF425866 AF425867 AF425868 AF425869 AL357079 AL451062 AL592548 AY167992 AY167993 AY167994 AY167995 AY167996 AY167997 AY167998 BC050380 CH471059 L23768
GenPept AAA35778 AAH50380 AAO13859 AAO13860 AAO13861 AAO13862 AAO13863 AAO13864 AAO13865 AAO13866 AAO13867 AAO13868 AAO13869 AAO13870 AAO13871 AAO13872 AAO13873 AAO13874 AAO13875 AAO13876 AAO13877 AAO38806 AAO38807 AAO38808 AAO38809 AAO38810 AAO38811 AAO38812 CAH71022 CAH71023 CAH71024 CAH71025 CAH71027 CAH71028 CAH71029 CAH71031 CAH71032 CAH71033 CAI16785 CAI16786 CAI16787 CAI16789 CAI16790 CAI16791 CAI16792 CAI16793 CAI16794 CAI16795 CAI22181 CAI22182 CAI22183 CAI22184 CAI22186 CAI22188 CAI22189 CAI22190 CAI22191 CAI22192 EAX07082 EAX07083
RNA Seq Atlas 6487