Version 5.4
Homo sapiens Gene: ST3GAL3
Summary
InnateDB Gene IDBG-97520.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ST3GAL3
Gene Name ST3 beta-galactoside alpha-2,3-sialyltransferase 3
Synonyms EIEE15; MRT12; SIAT6; ST3GALII; ST3GalIII; ST3N
Species Homo sapiens
Ensembl Gene ENSG00000126091
Encoded Proteins
IDBP-97522
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
IDBP-97524
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
IDBP-97526
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
IDBP-97528
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
IDBP-97530
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
IDBP-97532
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
IDBP-97534
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
IDBP-97540
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
IDBP-97542
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
IDBP-97544
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
IDBP-97546
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
IDBP-97548
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
IDBP-97550
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
IDBP-97552
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
IDBP-97554
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
IDBP-97556
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
IDBP-97558
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
IDBP-97560
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
IDBP-97562
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
IDBP-583556
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
IDBP-596600
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
IDBP-584296
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
IDBP-584540
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
IDBP-594412
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
IDBP-596781
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
IDBP-601053
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
IDBP-594884
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
IDBP-596276
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
IDBP-584827
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
IDBP-588399
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
IDBP-584040
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
IDBP-597301
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
IDBP-584483
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
IDBP-589530
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
IDBP-584229
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
IDBP-586555
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi apparatus but can be proteolytically processed to a soluble form. This protein is a member of glycosyltransferase family 29. Mutations in this gene have been associated with autosomal recessive nonsymdromic mental retardation-12 (MRT12). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:43705824-43931165
Strand Forward strand
Band p34.1
Transcripts
ENST00000361392 ENSP00000355341
ENST00000361400 ENSP00000354748
ENST00000262915 ENSP00000262915
ENST00000347631 ENSP00000317192
ENST00000330208 ENSP00000333494
ENST00000361746 ENSP00000354657
ENST00000351035 ENSP00000316999
ENST00000372374 ENSP00000361449
ENST00000372372 ENSP00000361447
ENST00000335430 ENSP00000335633
ENST00000353126 ENSP00000330463
ENST00000361812 ENSP00000355201
ENST00000372368 ENSP00000361443
ENST00000332628 ENSP00000329755
ENST00000372369 ENSP00000361444
ENST00000372365 ENSP00000361440
ENST00000372366 ENSP00000361441
ENST00000372367 ENSP00000361442
ENST00000372362 ENSP00000361437
ENST00000489897 ENSP00000437206
ENST00000479383 ENSP00000432214
ENST00000484868
ENST00000490541 ENSP00000435018
ENST00000469715 ENSP00000431700
ENST00000461066 ENSP00000433668
ENST00000461375
ENST00000490502 ENSP00000436298
ENST00000495482
ENST00000532911 ENSP00000431816
ENST00000530154 ENSP00000434686
ENST00000531451 ENSP00000435603
ENST00000528371 ENSP00000434876
ENST00000531993 ENSP00000432682
ENST00000533933 ENSP00000432965
ENST00000533212 ENSP00000435621
ENST00000533997 ENSP00000432071
ENST00000530581 ENSP00000437293
ENST00000531816 ENSP00000434378
ENST00000545417 ENSP00000439634
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity
GO:0008118 N-acetyllactosaminide alpha-2,3-sialyltransferase activity
GO:0008373 sialyltransferase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006486 protein glycosylation
GO:0016266 O-glycan processing
GO:0018146 keratan sulfate biosynthetic process
GO:0030203 glycosaminoglycan metabolic process
GO:0042339 keratan sulfate metabolic process
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0044281 small molecule metabolic process
GO:0097503 sialylation
Cellular Component
GO:0000139 Golgi membrane
GO:0005576 extracellular region
GO:0030173 integral component of Golgi membrane
GO:0032580 Golgi cisterna membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028538
View Gene Order
ENSBTAG00000017656
Not yet available
Pathways
NETPATH
REACTOME
REACT_118798
Pre-NOTCH Processing in Golgi pathway
REACT_115835
Termination of O-glycan biosynthesis pathway
REACT_115606
O-linked glycosylation of mucins pathway
REACT_22433
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
REACT_22426
Asparagine N-linked glycosylation pathway
REACT_121120
Keratan sulfate biosynthesis pathway
REACT_147853
Mucopolysaccharidoses pathway
REACT_22161
Post-translational protein modification pathway
REACT_118744
Pre-NOTCH Expression and Processing pathway
REACT_200783
Myoclonic epilepsy of Lafora pathway
REACT_267711
Defective B4GALT7 causes EDS, progeroid type pathway
REACT_267713
Defective CHST6 causes MCDC1 pathway
REACT_121288
Keratan sulfate/keratin metabolism pathway
REACT_147719
MPS VI - Maroteaux-Lamy syndrome pathway
REACT_267645
Defective PAPSS2 causes SEMD-PA pathway
REACT_474
Metabolism of carbohydrates pathway
REACT_147749
MPS IIID - Sanfilippo syndrome D pathway
REACT_22387
Synthesis of substrates in N-glycan biosythesis pathway
REACT_267662
Defective SLC26A2 causes chondrodysplasias pathway
REACT_111102
Signal Transduction pathway
REACT_200727
O-linked glycosylation pathway
REACT_200874
Sialic acid metabolism pathway
REACT_147739
MPS IX - Natowicz syndrome pathway
REACT_267674
Defective EXT1 causes exostoses 1, TRPS2 and CHDS pathway
REACT_17015
Metabolism of proteins pathway
REACT_267642
Defective CHST14 causes EDS, musculocontractural type pathway
REACT_147798
MPS IV - Morquio syndrome B pathway
REACT_267659
Defective B3GAT3 causes JDSSDHD pathway
REACT_267708
Defective CHST3 causes SEDCJD pathway
REACT_147825
MPS IV - Morquio syndrome A pathway
REACT_267654
Defective EXT2 causes exostoses 2 pathway
REACT_267707
Diseases associated with glycosaminoglycan metabolism pathway
REACT_147734
MPS II - Hunter syndrome pathway
REACT_299
Signaling by NOTCH pathway
REACT_267635
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) pathway
REACT_121315
Glycosaminoglycan metabolism pathway
REACT_267705
Diseases of glycosylation pathway
REACT_147759
MPS VII - Sly syndrome pathway
REACT_267682
Defective CHSY1 causes TPBS pathway
REACT_111217
Metabolism pathway
REACT_147857
MPS I - Hurler syndrome pathway
REACT_147753
MPS IIIA - Sanfilippo syndrome A pathway
REACT_147860
MPS IIIC - Sanfilippo syndrome C pathway
REACT_116125
Disease pathway
REACT_200833
Glycogen storage diseases pathway
REACT_147788
MPS IIIB - Sanfilippo syndrome B pathway
KEGG
hsa00601
Glycosphingolipid biosynthesis pathway
hsa00533
Glycosaminoglycan biosynthesis pathway
hsa00514
Other types of O-glycan biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.576181 Hs.597915
RefSeq NM_001270459 NM_001270460 NM_001270461 NM_001270462 NM_001270463 NM_001270464 NM_001270465 NM_001270466 NM_006279 NM_174963 NM_174964 NM_174965 NM_174966 NM_174967 NM_174968 NM_174969 NM_174970 NM_174971
HUGO
OMIM
CCDS CCDS492 CCDS493 CCDS494 CCDS495 CCDS496 CCDS497 CCDS498 CCDS499 CCDS500 CCDS53310 CCDS57988 CCDS57989 CCDS57990 CCDS57991 CCDS57992 CCDS57993 CCDS57994
HPRD 05930
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca