Homo sapiens Gene: CYP4A22
Summary
InnateDB Gene IDBG-98250.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CYP4A22
Gene Name cytochrome P450, family 4, subfamily A, polypeptide 22
Synonyms CP4Y; CYP4A2; CYP4AII;
Species Homo sapiens
Ensembl Gene ENSG00000162365
Encoded Proteins
cytochrome P450, family 4, subfamily A, polypeptide 22
cytochrome P450, family 4, subfamily A, polypeptide 22
cytochrome P450, family 4, subfamily A, polypeptide 22
cytochrome P450, family 4, subfamily A, polypeptide 22
cytochrome P450, family 4, subfamily A, polypeptide 22
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 1p33. [provided by RefSeq, Jul 2008]
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:47137435-47149741
Strand Forward strand
Band p33
Transcripts
ENST00000371891 ENSP00000360958
ENST00000371890 ENSP00000360957
ENST00000294337 ENSP00000294337
ENST00000490948
ENST00000485117
ENST00000620131 ENSP00000479019
ENST00000619754 ENSP00000482952
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0018685 alkane 1-monooxygenase activity
GO:0020037 heme binding
GO:0052869 arachidonic acid omega-hydroxylase activity
Biological Process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
Arachidonic acid metabolism pathway
Cytochrome P450 - arranged by substrate type pathway
Synthesis of Leukotrienes (LT) and Eoxins (EX) pathway
Fatty acids pathway
Metabolism pathway
Biological oxidations pathway
Eicosanoids pathway
Miscellaneous substrates pathway
Phase 1 - Functionalization of compounds pathway
KEGG
Fatty acid degradation pathway
Arachidonic acid metabolism pathway
Retinol metabolism pathway
Vascular smooth muscle contraction pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q5TCH4
TrEMBL
UniProt Splice Variant
Entrez Gene 284541
UniGene Hs.726474
RefSeq NM_001010969 XM_005270767 XM_005270768
HUGO HGNC:20575
OMIM 601310 615341
CCDS CCDS30707
HPRD 16776
IMGT
EMBL AF208532 AL135960 AY280371 AY280372 BC148248
GenPept AAF76722 AAI48249 AAQ21367 AAQ21368 CAI19737 CAI19738
RNA Seq Atlas 1579 284541