Version 5.4
Homo sapiens Gene: TAL1
Summary
InnateDB Gene IDBG-98262.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TAL1
Gene Name T-cell acute lymphocytic leukemia 1
Synonyms bHLHa17; SCL; tal-1; TCL5
Species Homo sapiens
Ensembl Gene ENSG00000162367
Encoded Proteins
IDBP-98264
T-cell acute lymphocytic leukemia 1
IDBP-98268
T-cell acute lymphocytic leukemia 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 1:47216290-47232220
Strand Reverse strand
Band p33
Transcripts
ENST00000371884 ENSP00000360951
ENST00000294339 ENSP00000294339
ENST00000459729
ENST00000464796
ENST00000481091
ENST00000465912
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 76 experimentally validated interaction(s) in this database.
They are also associated with 292 interaction(s) predicted by orthology.
Experimentally validated
Total 79 [view]
Protein-Protein 75 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 292 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000976 transcription regulatory region sequence-specific DNA binding
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001085 RNA polymerase II transcription factor binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0042826 histone deacetylase binding
GO:0044212 transcription regulatory region DNA binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0070888 E-box binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001525 angiogenesis
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0007626 locomotory behavior
GO:0021527 spinal cord association neuron differentiation
GO:0030097 hemopoiesis
GO:0030099 myeloid cell differentiation
GO:0030182 neuron differentiation
GO:0030218 erythrocyte differentiation
GO:0030219 megakaryocyte differentiation
GO:0030220 platelet formation
GO:0030221 basophil differentiation
GO:0031334 positive regulation of protein complex assembly
GO:0035162 embryonic hemopoiesis
GO:0035855 megakaryocyte development
GO:0042127 regulation of cell proliferation
GO:0043249 erythrocyte maturation
GO:0045165 cell fate commitment
GO:0045637 regulation of myeloid cell differentiation
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045799 positive regulation of chromatin assembly or disassembly
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045931 positive regulation of mitotic cell cycle
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048699 generation of neurons
GO:0051781 positive regulation of cell division
GO:0060018 astrocyte fate commitment
GO:0060216 definitive hemopoiesis
GO:0060217 hemangioblast cell differentiation
GO:0060218 hematopoietic stem cell differentiation
GO:0060375 regulation of mast cell differentiation
GO:2000036 regulation of stem cell maintenance
Cellular Component
GO:0000118 histone deacetylase complex
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0033193 Lsd1/2 complex
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028717
View Gene Order
ENSBTAG00000005029
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.705618 Hs.720349 Hs.737706
RefSeq NM_001287347 NM_001290403 NM_001290404 NM_001290405 NM_001290406 NM_003189 XM_005271159 XM_005271160 XM_006710862 XM_006710863
HUGO
OMIM
CCDS CCDS547
HPRD 01753
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca