Version 5.4
Homo sapiens Gene: EZR
Summary
InnateDB Gene IDBG-98477.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EZR
Gene Name ezrin
Synonyms CVIL; CVL; HEL-S-105; VIL2
Species Homo sapiens
Ensembl Gene ENSG00000092820
Encoded Proteins
IDBP-98479
ezrin
IDBP-98481
ezrin
IDBP-246189
ezrin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:158765741-158819412
Strand Reverse strand
Band q25.3
Transcripts
ENST00000337147 ENSP00000338934
ENST00000367075 ENSP00000356042
ENST00000392177 ENSP00000376016
ENST00000476189
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 138 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 138 [view]
Protein-Protein 135 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0008092 cytoskeletal protein binding
GO:0019904 protein domain specific binding
GO:0032403 protein complex binding
GO:0044822 poly(A) RNA binding
GO:0050839 cell adhesion molecule binding
GO:0051015 actin filament binding
Biological Process
GO:0007016 cytoskeletal anchoring at plasma membrane
GO:0007159 leukocyte cell-cell adhesion
GO:0007411 axon guidance
GO:0008360 regulation of cell shape
GO:0010628 positive regulation of gene expression
GO:0022614 membrane to membrane docking
GO:0030855 epithelial cell differentiation
GO:0031623 receptor internalization
GO:0035088 establishment or maintenance of apical/basal cell polarity
GO:0046847 filopodium assembly
GO:0051017 actin filament bundle assembly
GO:0061028 establishment of endothelial barrier
Cellular Component
GO:0001726 ruffle
GO:0001931 uropod
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005884 actin filament
GO:0005886 plasma membrane
GO:0005902 microvillus
GO:0005925 focal adhesion
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0016324 apical plasma membrane
GO:0019898 extrinsic component of membrane
GO:0030175 filopodium
GO:0030315 T-tubule
GO:0030863 cortical cytoskeleton
GO:0031528 microvillus membrane
GO:0032587 ruffle membrane
GO:0036064 ciliary basal body
GO:0044297 cell body
GO:0044393 microspike
GO:0045121 membrane raft
GO:0045177 apical part of cell
GO:0051286 cell tip
GO:0070062 extracellular vesicular exosome
GO:0097449 astrocyte projection
GO:0097454 Schwann cell microvillus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000052397
View Gene Order
ENSBTAG00000010347
Not yet available
Pathways
NETPATH
NetPath_6
KitReceptor pathway
REACTOME
REACT_22365
Recycling pathway of L1 pathway
REACT_22205
L1CAM interactions pathway
REACT_22237
Netrin-1 signaling pathway
REACT_111045
Developmental Biology pathway
REACT_18266
Axon guidance pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa05130
Pathogenic Escherichia coli infection pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa04971
Gastric acid secretion pathway
INOH
PID NCI
syndecan_2_pathway
Syndecan-2-mediated signaling events
lkb1_pathway
LKB1 signaling events
faspathway
FAS (CD95) signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.487027
RefSeq NM_001111077 NM_003379 XM_006715561
HUGO
OMIM
CCDS CCDS5258
HPRD 00475
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca