Homo sapiens Gene: SOD2
Summary
InnateDB Gene IDBG-98553.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SOD2
Gene Name superoxide dismutase 2, mitochondrial
Synonyms IPOB; MNSOD; MVCD6;
Species Homo sapiens
Ensembl Gene ENSG00000112096
Encoded Proteins
superoxide dismutase 2, mitochondrial
superoxide dismutase 2, mitochondrial
superoxide dismutase 2, mitochondrial
superoxide dismutase 2, mitochondrial
superoxide dismutase 2, mitochondrial
superoxide dismutase 2, mitochondrial
superoxide dismutase 2, mitochondrial
superoxide dismutase 2, mitochondrial
superoxide dismutase 2, mitochondrial
superoxide dismutase 2, mitochondrial
superoxide dismutase 2, mitochondrial
superoxide dismutase 2, mitochondrial
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:159669057-159762529
Strand Reverse strand
Band q25.3
Transcripts
ENST00000367055 ENSP00000356022
ENST00000367054 ENSP00000356021
ENST00000337404 ENSP00000337127
ENST00000401980 ENSP00000384196
ENST00000444946 ENSP00000404804
ENST00000452684 ENSP00000406713
ENST00000546260 ENSP00000440131
ENST00000538183 ENSP00000446252
ENST00000546087 ENSP00000442920
ENST00000535459
ENST00000541573
ENST00000540491
ENST00000545162 ENSP00000441362
ENST00000535561 ENSP00000445015
ENST00000537657 ENSP00000439191
ENST00000535372
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 24 [view]
Protein-Protein 21 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0004784 superoxide dismutase activity
GO:0005515 protein binding
GO:0019825 oxygen binding
GO:0030145 manganese ion binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0000302 response to reactive oxygen species
GO:0000303 response to superoxide
GO:0001306 age-dependent response to oxidative stress
GO:0001315 age-dependent response to reactive oxygen species
GO:0001666 response to hypoxia
GO:0001836 release of cytochrome c from mitochondria
GO:0001889 liver development
GO:0003032 detection of oxygen
GO:0003069 vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006749 glutathione metabolic process
GO:0006801 superoxide metabolic process
GO:0006979 response to oxidative stress
GO:0007005 mitochondrion organization
GO:0007507 heart development
GO:0007568 aging
GO:0007626 locomotory behavior
GO:0008217 regulation of blood pressure
GO:0008285 negative regulation of cell proliferation
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0008637 apoptotic mitochondrial changes
GO:0009314 response to radiation
GO:0009409 response to cold
GO:0009791 post-embryonic development
GO:0010042 response to manganese ion
GO:0010043 response to zinc ion
GO:0010269 response to selenium ion
GO:0010332 response to gamma radiation
GO:0014823 response to activity
GO:0019430 removal of superoxide radicals
GO:0022904 respiratory electron transport chain
GO:0030097 hemopoiesis
GO:0031667 response to nutrient levels
GO:0032364 oxygen homeostasis
GO:0032496 response to lipopolysaccharide
GO:0033591 response to L-ascorbic acid
GO:0034021 response to silicon dioxide
GO:0035900 response to isolation stress
GO:0035902 response to immobilization stress
GO:0042311 vasodilation
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0042554 superoxide anion generation
GO:0042743 hydrogen peroxide metabolic process
GO:0043066 negative regulation of apoptotic process
GO:0043524 negative regulation of neuron apoptotic process
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045599 negative regulation of fat cell differentiation
GO:0046686 response to cadmium ion
GO:0048147 negative regulation of fibroblast proliferation
GO:0048666 neuron development
GO:0048678 response to axon injury
GO:0048773 erythrophore differentiation
GO:0050665 hydrogen peroxide biosynthetic process
GO:0050790 regulation of catalytic activity
GO:0051260 protein homooligomerization
GO:0051289 protein homotetramerization
GO:0051602 response to electrical stimulus
GO:0051881 regulation of mitochondrial membrane potential
GO:0055072 iron ion homeostasis
GO:0055093 response to hyperoxia
GO:0055114 oxidation-reduction process
GO:0071000 response to magnetism
GO:0071361 cellular response to ethanol
GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
GO:0042645 mitochondrial nucleoid
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Cellular responses to stress pathway
Detoxification of Reactive Oxygen Species pathway
KEGG
Peroxisome pathway
Huntington's disease pathway
INOH
PID BIOCARTA
Cardiac protection against ros [Biocarta view]
Erythropoietin mediated neuroprotection through nf-kb [Biocarta view]
The igf-1 receptor and longevity [Biocarta view]
PID NCI
FoxO family signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.487046 Hs.702118 Hs.712708 Hs.731637
RefSeq NM_000636 NM_001024465 NM_001024466
HUGO
OMIM
CCDS CCDS34564 CCDS5265
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas