Version 5.4
Homo sapiens Gene: MPP6
Summary
InnateDB Gene IDBG-9862.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MPP6
Gene Name membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000105926
Encoded Proteins
IDBP-9864
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
IDBP-237418
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
IDBP-294789
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
IDBP-368410
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
IDBP-368424
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
IDBP-368438
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
IDBP-812772
membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1; MIM 601014), ZO1-like (see TJP1; MIM 601009), p55-like (see MPP1; MIM 305360), and LIN2-like (see CASK; MIM 300172), based on their size and the presence of additional domains. MPP6 is a member of the p55-like MAGUK subfamily (Tseng et al., 2001 [PubMed 11311936]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:24573268-24694193
Strand Forward strand
Band p15.3
Transcripts
ENST00000222644 ENSP00000222644
ENST00000396475 ENSP00000379737
ENST00000409761 ENSP00000386262
ENST00000432190 ENSP00000395859
ENST00000430180 ENSP00000391020
ENST00000426450 ENSP00000400515
ENST00000472674
ENST00000464384 ENSP00000473560
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 28 [view]
Protein-Protein 25 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030165 PDZ domain binding
Biological Process
GO:0006461 protein complex assembly
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038388
View Gene Order
ENSBTAG00000015303
Not yet available
Cross-References
SwissProt
TrEMBL B8ZZG1
UniProt Splice Variant
Entrez Gene 51678
UniGene Hs.533355
RefSeq NM_016447 XM_005249775 XM_006715738 XM_006715739 XM_006715740
HUGO HGNC:18167
OMIM 606959
CCDS CCDS5388
HPRD 09509
IMGT
EMBL AC003093 AC005084 CH471073
GenPept EAW93808
RNA Seq Atlas 51678

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca