Version 5.4
Homo sapiens Gene: TMEM59
Summary
InnateDB Gene IDBG-98894.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TMEM59
Gene Name transmembrane protein 59
Synonyms C1orf8; HSPC001
Species Homo sapiens
Ensembl Gene ENSG00000116209
Encoded Proteins
IDBP-98896
transmembrane protein 59
IDBP-98898
transmembrane protein 59
IDBP-98900
transmembrane protein 59
IDBP-98902
transmembrane protein 59
IDBP-98906
transmembrane protein 59
IDBP-384593
transmembrane protein 59
IDBP-384594
transmembrane protein 59
IDBP-384596
transmembrane protein 59
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 1:54031663-54053504
Strand Reverse strand
Band p32.3
Transcripts
ENST00000371348 ENSP00000360399
ENST00000234831 ENSP00000234831
ENST00000371344 ENSP00000360395
ENST00000371341 ENSP00000360392
ENST00000371337 ENSP00000360388
ENST00000440019 ENSP00000399761
ENST00000420738 ENSP00000413792
ENST00000452421 ENSP00000397772
ENST00000470395
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 9 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004175 endopeptidase activity
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005515 protein binding
Biological Process
GO:0006508 proteolysis
GO:0006914 autophagy
GO:0010508 positive regulation of autophagy
GO:0010955 negative regulation of protein processing
GO:0090005 negative regulation of establishment of protein localization to plasma membrane
GO:0090285 negative regulation of protein glycosylation in Golgi
Cellular Component
GO:0000137 Golgi cis cisterna
GO:0000138 Golgi trans cisterna
GO:0000139 Golgi membrane
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005770 late endosome
GO:0005797 Golgi medial cisterna
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0031902 late endosome membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028618
View Gene Order
ENSBTAG00000009526
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_004872 XM_005271350
HUGO
OMIM
CCDS CCDS586
HPRD 12731
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca