Version 5.4
Homo sapiens Gene: BRP44L
Summary
InnateDB Gene IDBG-98940.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BRP44L
Gene Name mitochondrial pyruvate carrier 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000060762
Encoded Proteins
IDBP-98942
brain protein 44-like
IDBP-98944
brain protein 44-like
IDBP-807497
mitochondrial pyruvate carrier 1
IDBP-807499
mitochondrial pyruvate carrier 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is part of an MPC1/MPC2 heterodimer that is responsible for transporting pyruvate into mitochondria. The encoded protein is found in the inner mitochondrial membrane. Defects in this gene are a cause of mitochondrial pyruvate carrier deficiency. Several transcript variants, some protein coding and one non-protein coding, have been found for this gene. [provided by RefSeq, Aug 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:166364919-166383013
Strand Reverse strand
Band q27
Transcripts
ENST00000360961 ENSP00000354223
ENST00000341756 ENSP00000340784
ENST00000366868
ENST00000487218
ENST00000475708
ENST00000621685 ENSP00000477853
ENST00000621630 ENSP00000479789
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0050833 pyruvate transmembrane transporter activity
Biological Process
GO:0006090 pyruvate metabolic process
GO:0006850 mitochondrial pyruvate transport
GO:0008150 biological_process
GO:0044237 cellular metabolic process
GO:0044281 small molecule metabolic process
GO:1901475 pyruvate transmembrane transport
Cellular Component
GO:0005575 cellular_component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000091498
View Gene Order
ENSBTAG00000027879
Not yet available
Pathways
NETPATH
REACTOME
REACT_2071
Pyruvate metabolism pathway
REACT_1046
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
REACT_111083
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_111217
Metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001270879 NM_016098
HUGO
OMIM
CCDS CCDS5293 CCDS75547
HPRD 07091
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca