InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NFIA

Summary

InnateDB Gene

IDBG-99286.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NFIA

Gene Name

nuclear factor I/A

Synonyms

CTF; NF-I/A; NF1-A; NFI-A; NFI-L

Species

Homo sapiens

Ensembl Gene

ENSG00000162599

Encoded Proteins

IDBP-99288

nuclear factor I/A

IDBP-99292

nuclear factor I/A

IDBP-810291

nuclear factor I/A

IDBP-99296

nuclear factor I/A

IDBP-99298

nuclear factor I/A

IDBP-99300

nuclear factor I/A

IDBP-295313

nuclear factor I/A

IDBP-295304

nuclear factor I/A

IDBP-810277

nuclear factor I/A

IDBP-484222

nuclear factor I/A

IDBP-810287

nuclear factor I/A

IDBP-810289

nuclear factor I/A

IDBP-810292

nuclear factor I/A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 26259914

[Mus musculus] During sepsis-induced generation of myeloid-derived suppressor cells, transcription factor Nfia represses Cdkn1a to arrest differentiation of Gr1+ CD11b+ cells.

Entrez Gene

Summary

This gene encodes a member of the NF1 (nuclear factor 1) family of transcription factors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:60865259-61462793

Strand

Forward strand

Band

p31.3

Transcripts

ENST00000371191	ENSP00000360233
ENST00000371189	ENSP00000360231
ENST00000357977	ENSP00000474462
ENST00000371187	ENSP00000360229
ENST00000371185	ENSP00000360227
ENST00000371184	ENSP00000360226
ENST00000407417	ENSP00000384680
ENST00000403491	ENSP00000384523
ENST00000476646	ENSP00000474461
ENST00000479364
ENST00000485903	ENSP00000419785
ENST00000496712	ENSP00000473830
ENST00000482020	ENSP00000474806
ENST00000493627	ENSP00000474817

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.

Experimentally validated
Total	34 [view]
Protein-Protein	33 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding

Biological Process

GO:0006260	DNA replication
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0014070	response to organic cyclic compound
GO:0019079	viral genome replication
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000028565

View Gene Order

ENSBTAG00000000074

Not yet available

Pathways

NETPATH

REACTOME

REACT_22339

RNA Polymerase III Abortive And Retractive Initiation pathway

REACT_63

RNA Polymerase III Transcription Termination pathway

REACT_1371

RNA Polymerase III Transcription pathway

REACT_21352

RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway

REACT_71

Gene Expression pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.191911 Hs.678749 Hs.710546 Hs.716706

RefSeq

NM_001134673 NM_001145511 NM_001145512 NM_005595

HUGO

OMIM

CCDS

CCDS44156 CCDS53321 CCDS53322 CCDS615

HPRD

09007

IMGT

EMBL

GenPept

RNA Seq Atlas