Version 5.4
Homo sapiens Gene: ANGPTL3
Summary
InnateDB Gene IDBG-99367.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ANGPTL3
Gene Name angiopoietin-like 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000132855
Encoded Proteins
IDBP-99369
angiopoietin-like 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of a family of secreted proteins that function in angiogenesis. The encoded protein, which is expressed predominantly in the liver, is further processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metablism, while the C-terminal chain may be involved in angiogenesis. Mutations in this gene cause familial hypobetalipoproteinemia type 2. [provided by RefSeq, Feb 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:62597487-62606159
Strand Forward strand
Band p31.3
Transcripts
ENST00000371129 ENSP00000360170
ENST00000482591
ENST00000493994
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004857 enzyme inhibitor activity
GO:0004859 phospholipase inhibitor activity
GO:0005178 integrin binding
GO:0008083 growth factor activity
Biological Process
GO:0006071 glycerol metabolic process
GO:0006631 fatty acid metabolic process
GO:0006644 phospholipid metabolic process
GO:0007160 cell-matrix adhesion
GO:0007165 signal transduction
GO:0007229 integrin-mediated signaling pathway
GO:0008203 cholesterol metabolic process
GO:0009395 phospholipid catabolic process
GO:0009725 response to hormone
GO:0010519 negative regulation of phospholipase activity
GO:0019915 lipid storage
GO:0030335 positive regulation of cell migration
GO:0042632 cholesterol homeostasis
GO:0045766 positive regulation of angiogenesis
GO:0048844 artery morphogenesis
GO:0050996 positive regulation of lipid catabolic process
GO:0051005 negative regulation of lipoprotein lipase activity
GO:0055088 lipid homeostasis
GO:0055090 acylglycerol homeostasis
GO:0055091 phospholipid homeostasis
GO:0070328 triglyceride homeostasis
Cellular Component
GO:0005615 extracellular space
GO:0009986 cell surface
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028553
View Gene Order
ENSBTAG00000021386
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
avb3_integrin_pathway
Integrins in angiogenesis
Cross-References
SwissProt Q9Y5C1
TrEMBL
UniProt Splice Variant
Entrez Gene 27329
UniGene Hs.209153 Hs.736217
RefSeq NM_014495
HUGO HGNC:491
OMIM 604774
CCDS CCDS622
HPRD
IMGT
EMBL AF152562 AK315304 AY358273 AY569015 BC007059 BC058287 CH471059 FJ515851
GenPept AAD34156 AAH07059 AAH58287 AAQ88640 AAS66984 ACS13743 BAG37708 EAX06583
RNA Seq Atlas 27329

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca