InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: AK4

Summary

InnateDB Gene

IDBG-99453.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AK4

Gene Name

adenylate kinase 4

Synonyms

AK 4; AK3; AK3L1; AK3L2

Species

Homo sapiens

Ensembl Gene

ENSG00000162433

Encoded Proteins

IDBP-99457

adenylate kinase 4

IDBP-239777

adenylate kinase 4

IDBP-593298

adenylate kinase 4

IDBP-588929

adenylate kinase 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the adenylate kinase family of enzymes. The encoded protein is localized to the mitochondrial matrix. Adenylate kinases regulate the adenine and guanine nucleotide compositions within a cell by catalyzing the reversible transfer of phosphate group among these nucleotides. Five isozymes of adenylate kinase have been identified in vertebrates. Expression of these isozymes is tissue-specific and developmentally regulated. A pseudogene for this gene has been located on chromosome 17. Three transcript variants encoding the same protein have been identified for this gene. Sequence alignment suggests that the gene defined by NM_013410, NM_203464, and NM_001005353 is located on chromosome 1. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:65147549-65232145

Strand

Forward strand

Band

p31.3

Transcripts

ENST00000327299	ENSP00000322175
ENST00000395334	ENSP00000378743
ENST00000497030
ENST00000470888
ENST00000474968
ENST00000479060
ENST00000546702	ENSP00000448458
ENST00000545314	ENSP00000445912

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004017	adenylate kinase activity
GO:0004550	nucleoside diphosphate kinase activity
GO:0005524	ATP binding
GO:0005525	GTP binding
GO:0016776	phosphotransferase activity, phosphate group as acceptor
GO:0046899	nucleoside triphosphate adenylate kinase activity

Biological Process

GO:0001889	liver development
GO:0006165	nucleoside diphosphate phosphorylation
GO:0006172	ADP biosynthetic process
GO:0007420	brain development
GO:0009142	nucleoside triphosphate biosynthetic process
GO:0042493	response to drug
GO:0046033	AMP metabolic process
GO:0046034	ATP metabolic process
GO:0046039	GTP metabolic process
GO:0046939	nucleotide phosphorylation

Cellular Component

GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000028527

View Gene Order

ENSBTAG00000030674

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa00230

Purine metabolism pathway

INOH

INOH website

Purine nucleotides nucleosides metabolism pathway

PID NCI

Cross-References

SwissProt

P27144

TrEMBL

D3DQ64

UniProt Splice Variant

Entrez Gene

205

UniGene

Hs.10862 Hs.505172 Hs.596190 Hs.596232 Hs.599611 Hs.617151 Hs.662902

RefSeq

NM_013410 XM_003119530 NM_001005353 NM_203464

HUGO

HGNC:363

OMIM

103030

CCDS

CCDS629

HPRD

00048

IMGT

EMBL

AC099680 AK313611 AL356212 BC016180 BC040224 BC066944 BC136886 BC136887 BC146653 BC148270 CH471059 CR456830 X60673

GenPept

AAH16180 AAH40224 AAH66944 AAI36887 AAI36888 AAI46654 AAI48271 BAG36374 CAA43088 CAG33111 CAI22412 EAX06538 EAX06540 EAX06541 EAX06542 EAX06544

RNA Seq Atlas

100507855 205