Version 5.4
Homo sapiens Gene: DNAJC6
Summary
InnateDB Gene IDBG-99461.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DNAJC6
Gene Name DnaJ (Hsp40) homolog, subfamily C, member 6
Synonyms DJC6; PARK19
Species Homo sapiens
Ensembl Gene ENSG00000116675
Encoded Proteins
IDBP-99463
DnaJ (Hsp40) homolog, subfamily C, member 6
IDBP-99465
DnaJ (Hsp40) homolog, subfamily C, member 6
IDBP-239791
DnaJ (Hsp40) homolog, subfamily C, member 6
IDBP-807936
DnaJ (Hsp40) homolog, subfamily C, member 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary DNAJC6 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus, a glycine/phenylalanine (G/F)-rich region, and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain (Ohtsuka and Hata, 2000 [PubMed 11147971]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:65248219-65415869
Strand Forward strand
Band p31.3
Transcripts
ENST00000263441 ENSP00000263441
ENST00000371069 ENSP00000360108
ENST00000395325 ENSP00000378735
ENST00000463018
ENST00000494710 ENSP00000473821
ENST00000483402
ENST00000472787
ENST00000498720
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0016791 phosphatase activity
GO:0017124 SH3 domain binding
Biological Process
GO:0006892 post-Golgi vesicle-mediated transport
GO:0008219 cell death
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0061024 membrane organization
GO:0072318 clathrin coat disassembly
GO:2000369 regulation of clathrin-mediated endocytosis
Cellular Component
GO:0005829 cytosol
GO:0045202 synapse
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028528
View Gene Order
ENSBTAG00000030749
Not yet available
Pathways
NETPATH
REACTOME
REACT_19287
Lysosome Vesicle Biogenesis pathway
REACT_19400
Golgi Associated Vesicle Biogenesis pathway
REACT_19187
Clathrin derived vesicle budding pathway
REACT_11235
trans-Golgi Network Vesicle Budding pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04144
Endocytosis pathway
INOH
PID NCI
Cross-References
SwissProt O75061
TrEMBL S4R305
UniProt Splice Variant
Entrez Gene 9829
UniGene Hs.647643
RefSeq NM_001256864 NM_001256865 NM_014787
HUGO HGNC:15469
OMIM 608375
CCDS CCDS30739 CCDS58004 CCDS58005
HPRD
IMGT
EMBL AB007942 AC119800 AK296408 AL139294 AL355487 AL356212 BC051722 BC109279 BC109280 CH471059
GenPept AAH51722 AAI09280 AAI09281 BAA32318 BAH12344 CAI18997 CAI18999 CAI23547 CAI23548 EAX06533 EAX06534 EAX06536 EAX06537
RNA Seq Atlas 9829

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca