Version 5.4
Homo sapiens Gene: DIRAS3
Summary
InnateDB Gene IDBG-99588.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DIRAS3
Gene Name DIRAS family, GTP-binding RAS-like 3
Synonyms ARHI; NOEY2
Species Homo sapiens
Ensembl Gene ENSG00000162595
Encoded Proteins
IDBP-99590
DIRAS family, GTP-binding RAS-like 3
IDBP-240048
DIRAS family, GTP-binding RAS-like 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the ras superfamily, and is expressed in normal ovarian and breast epithelial cells, but not in ovarian and breast cancers. It is an imprinted gene, with monoallelic expression of the paternal allele, which is associated with growth suppression. Thus, this gene appears to be a putative tumor suppressor gene whose function is abrogated in ovarian and breast cancers. [provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:68045962-68051631
Strand Reverse strand
Band p31.3
Transcripts
ENST00000370981 ENSP00000360020
ENST00000395201 ENSP00000378627
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 0
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
Biological Process
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0006184 GTP catabolic process
GO:0006349 regulation of gene expression by genetic imprinting
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0015031 protein transport
Cellular Component
GO:0005622 intracellular
GO:0005886 plasma membrane
GO:0016020 membrane
Orthologs
No orthologs found for this gene
Cross-References
SwissProt O95661
TrEMBL
UniProt Splice Variant
Entrez Gene 9077
UniGene Hs.194695 Hs.739323
RefSeq NM_004675 XM_006711027
HUGO HGNC:687
OMIM 605193
CCDS CCDS641
HPRD 05547
IMGT
EMBL AF202543 AK021882 AL157407 BC005362 CH471059 CR541870 CR541892 U96750
GenPept AAD03164 AAG35625 AAH05362 BAG51055 CAG46668 CAG46690 CAI21991 EAX06483
RNA Seq Atlas 9077

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca