Homo sapiens Gene: RABGGTB
Summary
InnateDB Gene IDBG-99771.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RABGGTB
Gene Name Rab geranylgeranyltransferase, beta subunit
Synonyms GGTB;
Species Homo sapiens
Ensembl Gene ENSG00000137955
Encoded Proteins
Rab geranylgeranyltransferase, beta subunit
Rab geranylgeranyltransferase, beta subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the beta-subunit of the enzyme Rab geranylgeranyl-transferase (RabGGTase), which belongs to the protein prenyltransferase family. RabGGTase catalyzes the post-translational addition of geranylgeranyl groups to C-terminal cysteine residues of Rab GTPases. Three small nucleolar RNA genes are present in the intronic regions of this gene. Alternately spliced transcript variants have been observed for this gene. A pseudogene associated with this gene is located on chromosome 3. [provided by RefSeq, Jan 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:75786197-75795079
Strand Forward strand
Band p31.1
Transcripts
ENST00000319942 ENSP00000317473
ENST00000370826 ENSP00000359862
ENST00000496055
ENST00000473406
ENST00000485459
ENST00000497648
ENST00000462042
ENST00000470201
ENST00000471759
ENST00000491266
ENST00000461653
ENST00000489450
ENST00000467748
ENST00000459697
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004663 Rab geranylgeranyltransferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0017137 Rab GTPase binding
Biological Process
GO:0006464 cellular protein modification process
GO:0007601 visual perception
GO:0018344 protein geranylgeranylation
Cellular Component
GO:0005968 Rab-protein geranylgeranyltransferase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Signaling events mediated by PRL
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.595216 Hs.608922
RefSeq NM_004582
HUGO
OMIM
CCDS CCDS669
HPRD 01532
IMGT
EMBL
GenPept
RNA Seq Atlas