InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SYDE2

Summary

InnateDB Protein

IDBP-100034.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SYDE2

Protein Name

synapse defective 1, Rho GTPase, homolog 2 (C. elegans)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000340594

InnateDB Gene

IDBG-100032 (SYDE2)

Protein Structure

UniProt Annotation

Function

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005100	Rho GTPase activator activity
GO:0005515	protein binding

Biological Process

GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0032862	activation of Rho GTPase activity
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

InterPro

IPR000008 C2 domain
IPR000198 Rho GTPase-activating protein domain
IPR008936 Rho GTPase activation protein

PFAM

PF00168
PF00620

PRINTS

PR00360

PIRSF

SMART

SM00239
SM00324

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q5VT97

PhosphoSite

PhosphoSite-Q5VT97

TrEMBL

UniProt Splice Variant

Entrez Gene

84144

UniGene

Hs.670497

RefSeq

NP_115560

HUGO

HGNC:25841

OMIM

CCDS

CCDS44169

HPRD

IMGT

EMBL

AK023877 AL603750 AL834286 BF196265

GenPept

BAB14711 CAD38960 CAH72669 CAH72670