Homo sapiens Protein: HS2ST1 | |||||||||||||
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Summary | |||||||||||||
InnateDB Protein | IDBP-100110.7 | ||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
Gene Symbol | HS2ST1 | ||||||||||||
Protein Name | heparan sulfate 2-O-sulfotransferase 1 | ||||||||||||
Synonyms | dJ604K5.2; | ||||||||||||
Species | Homo sapiens | ||||||||||||
Ensembl Protein | ENSP00000359582 | ||||||||||||
InnateDB Gene | IDBG-100108 (HS2ST1) | ||||||||||||
Protein Structure | |||||||||||||
UniProt Annotation | |||||||||||||
Function | Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high- affinity ligand-binding interactions and signaling processes. Mediates 2-O-sulfation of both L-iduronyl and D-glucuronyl residues (By similarity). {ECO:0000250}. | ||||||||||||
Subcellular Localization | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. | ||||||||||||
Disease Associations | |||||||||||||
Tissue Specificity | |||||||||||||
Comments | |||||||||||||
Interactions | |||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||
PDB ID | |||||||||||||
InterPro |
IPR005331
Sulfotransferase IPR009729 Galactose-3-O-sulfotransferase IPR027417 P-loop containing nucleoside triphosphate hydrolase |
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PFAM |
PF03567
PF06990 |
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PRINTS | |||||||||||||
PIRSF | |||||||||||||
SMART | |||||||||||||
TIGRFAMs | |||||||||||||
Post-translational Modifications | |||||||||||||
Modification | |||||||||||||
Cross-References | |||||||||||||
SwissProt | Q7LGA3 | ||||||||||||
PhosphoSite | PhosphoSite-Q7LGA3 | ||||||||||||
TrEMBL | K7EP71 | ||||||||||||
UniProt Splice Variant | |||||||||||||
Entrez Gene | 9653 | ||||||||||||
UniGene | Hs.743280 | ||||||||||||
RefSeq | NP_001127964 | ||||||||||||
HUGO | HGNC:5193 | ||||||||||||
OMIM | 604844 | ||||||||||||
CCDS | CCDS44171 | ||||||||||||
HPRD | 09215 | ||||||||||||
IMGT | |||||||||||||
EMBL | AB007917 AB024568 AC093155 AK002179 AL121989 AL139139 BC025384 BC025990 BC108735 CH471097 | ||||||||||||
GenPept | AAH25384 AAH25990 AAI08736 BAA32293 BAA89250 BAA92125 CAC04187 CAI19004 EAW73171 EAW73172 | ||||||||||||